Cognitive Functioning in People With Myasthenia Graivs: Impact on Daily Life Activities, Work, Disability and Quality of Life

NCT06718855 | Completed

• 1 other identifier: MYCOG
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

MYCOG primarily aims to estimate the prevalence of cognitive difficulties in patients with MG treated at Besta Institute. Secondary aims include: a) assess the degree to which cognitive difficulties are associated to work impairment, limitations in ADL, symptoms of anxiety and depression, fatigue, disability and QoL; b) assess whether patients with different MG types show different degrees of cognitive impairment; c) assess whether patients with different MG antibody profiles show different degrees of cognitive impairment; d) assess whether patients under different MG-specific pharmacological treatments show different degrees of cognitive impairment.

Conditions

Myasthenia Gravis

Keywords

Myasthenia Gravis; Cognitive Functioning; Disability; Activities of Daily Living; Quality of Life; Anxiety; Comorbidities; Work; Depression; Memory; Attention; Executive Functions; Cognitive Reserve

Outcome Measures

Primary Outcomes (1)

• GEMS

  Global examination of cognitive functioning

  22 months

Secondary Outcomes (10)

• CRIq

  22 months

• ENB-3

  22 months

• MG-DIS

  22 months

• MG-QOL15

  22 months

• MG-ADL

  22 months

Eligibility Criteria

• Age: 18 Years - 99 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Italian speakers, already followed at Besta Institute

You may qualify if:

• Patients with MG,
• followed-up at Besta institute
• aged 18-99,
• able to understand Italian language;

You may not qualify if:

• psychiatric comorbidies of psychotic nature;
• do not accept to participate on a voluntary basis;
• patients who should be excluded based on physician's judgement;
• patients who live in a nursing home for aged or disabled persons;
• respiratory impairment (patients under mechanical ventilation)

Sponsors & Collaborators

• Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta: lead

Study Sites (1)

Fondazione IRCCS Istituto Neurologico Carlo Besta

Milan, 20133, Italy

Location

MeSH Terms

Conditions

Myasthenia Gravis; Anxiety Disorders; Depression

Condition Hierarchy (Ancestors)

Paraneoplastic Syndromes, Nervous System; Nervous System Neoplasms; Neoplasms by Site; Neoplasms; Paraneoplastic Syndromes; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Neurodegenerative Diseases; Neuromuscular Junction Diseases; Neuromuscular Diseases; Autoimmune Diseases; Immune System Diseases; Mental Disorders; Behavioral Symptoms; Behavior

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 2, 2024
• First Posted: December 5, 2024
• Study Start: June 7, 2023
• Primary Completion: August 12, 2025
• Study Completion: September 30, 2025
• Last Updated: February 19, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

IT (1)