Caffeine and Sodium Bicarbonate Supplementation Effects on Resistance Training Performance

NCT06714331 | Completed Early Phase 1

• 1 other identifier: 20241611
• Study Type: interventional
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

This research aims to explore the effects of two supplements, caffeine and sodium bicarbonate, on acute (short-term) resistance training performance. The present study aims to assess the effects of caffeine and sodium bicarbonate supplementation on the number of repetitions, muscle activation, speed of movement, and fatigue during resistance training.

Conditions

Nutritional Supplementation; Resistance Training

Keywords

caffeine; sodium bicarbonate; strength; fatigue; resistance training

Outcome Measures

Primary Outcomes (2)

• Bench press repetitions to failure

  During familiarization participants 12 repetition maximum was calculated. After drinking supplement or control participants perform 6 sets of 12 repetition bench press maximum repetitions to failure. Outcome measure is the number of repetitions completed in each set of the 6 sets.

  45 minutes after last consumption of supplement or control drink solution.Order of bench press vs. knee extension is randomized.

• Knee extensions repetitions to failure

  During familiarization participants 12 repetition maximum was calculated. After drinking supplement or control participants perform 6 sets of 12 knee extension maximum repetitions to failure. Outcome measure is the number of repetitions completed in each of the 6 sets.

  45 minutes after last consumption of supplement or control drink solution. Order of bench press vs. knee extension is randomized.

Secondary Outcomes (4)

• Blood lactate

  Pre- (1 minute prior to ingestion of supplement solution) and post-tests (1 minute after each bout of bench press and knee extensions to failure). Each measure should take 5 seconds.

• Heart rate

  Heart rate (instantaneous feedback by monitor) will be recorded 10 seconds after every bench press and knee extension set in each condition/session (caffeine, sodium bicarbonate and control sessions).

• Rating of perceived exertion

  Recorded 20 seconds (response time = 2 seconds) after every bench press and knee extension set in each condition/session (caffeine, sodium bicarbonate and control sessions).

• Electromyography (EMG) root mean square (Mean amplitude)

  During every repetition to failure sets. Each set will take a maximum of 30 seconds. With fatigue from the repetitive 6 sets, the exercise and monitoring time will decrease.

Study Arms (3)

Caffeine

EXPERIMENTAL

Caffeine supplement is consumed at 3 time points (120, 90 and 45 minutes prior to testing) with participants drinking 300mL of a caffeine and water solution at each time for a total consumed volume of 900mL . Caffeine concentration - 3mg/kg or 0.003g/kg Each solution has MiO Liquid Water Enhancer to mask the taste.

Dietary Supplement: Supplements

Sodium bicarbonate

EXPERIMENTAL

Sodium bicarbonate supplement is consumed at 3 time points (120, 90 and 45 minutes prior to testing) with participants drinking 300mL of sodium bicarbonate solution at each time for a total consumed volume of 900mL. Sodium bicarbonate concentration - 0.3g/kg (Arm and Hammer brand) Each solution has MiO Liquid Water Enhancer to mask the taste.

Dietary Supplement: Supplements

Control

SHAM COMPARATOR

Control solution is MiO + 300mL water at 3 time points (120, 90 and 45 minutes prior to testing) with participants drinking 300mL of control solution at each time for a total consumed volume of 900mL.

Dietary Supplement: Supplements

Interventions

Supplements DIETARY_SUPPLEMENT

Supplements provided to subjects 2 hours prior to testing and drank at 2 hours, 90 minutes and 45 minutes before testing.

Caffeine; Control; Sodium bicarbonate

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• apparently healthy, physically active males and females between 18-40 years of age with regular (minimum three times a week) resistance training experience for the last 6 months and regular caffeine intake (at least once a day).

You may not qualify if:

• recent musculoskeletal or musculotendinous injuries

Sponsors & Collaborators

• Memorial University of Newfoundland: lead

Study Sites (1)

Memorial University of Newfoundland

St. John's, Newfoundland and Labrador, A1C 5S7, Canada

Location

MeSH Terms

Conditions

Fatigue

Condition Hierarchy (Ancestors)

Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• David G Behm, PhD

  Memorial University of Newfoundland

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: early phase 1
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: Separate investigator mixes the caffeine or sodium bicarbonate mixture solution. Other investigators conducting the data collection are blinded to the supplement or control mixture.
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: randomized, double-blind, placebo-controlled, cross-over study design with 1 intervention (supplements) with 3 arms (caffeine, sodium bicarbonate, control placebo).

Study Record Dates

• First Submitted: August 1, 2024
• First Posted: December 3, 2024
• Study Start: August 1, 2024
• Primary Completion: April 5, 2025
• Study Completion: May 5, 2025
• Last Updated: February 17, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)