Reflex Activity During Bone-Loading Exercises

NCT06711835 | Completed

• 1 other identifier: IstPRMTRH-EK1
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Load-bearing exercises are well-established as beneficial for bone health. Their role in promoting healthy bone development and managing osteoporosis is widely recognized. However, the neural mechanisms underlying the positive biomechanical effects of jumping-based load-bearing exercises, such as running, volleyball, basketball, tennis, and skipping rope, remain unclear. The aim of this study is to investigate whether jumping-based load-bearing exercises activate bone myoregulation reflex activity.

Conditions

Healthy

Keywords

Reflex; Vibration; Athletic Performance; Bone; Loading exercise

Outcome Measures

Primary Outcomes (1)

• Bone myoregulation reflex latency

  The measurement will be taken as the time difference between the moment of mechanical stimulation and the onset of the reflex response in the EMG. The unit of measurement for latency is milliseconds.

  Through study completion, an average of 8 weeks

Secondary Outcomes (1)

• Bereitschafts (Readiness) Potential

  Through study completion, an average of 8 weeks

Study Arms (2)

Group 1 (Normally Active Individuals)

EXPERIMENTAL

Individuals with Normal Daily Activities

Other: Whole-body vibration and Jumping

Group 2 (Athletic)

EXPERIMENTAL

Participants who regularly engage in sports activities such as marathon running, basketball, or volleyball

Other: Whole-body vibration and Jumping

Interventions

Whole-body vibration and Jumping OTHER

The subjects were first asked to jump in place 20 times, as if they were jumping rope. Then, whole-body vibration was applied. While the participants stood upright on the whole-body vibration device, low-amplitude (1.2 mm) vibrations were applied at eight different frequencies (25, 27, 29, 31, 33, 35, 37, 39 Hz), each lasting for 10 seconds, with a 5-second rest period in between.

Also known as: Loading exercise

Group 1 (Normally Active Individuals); Group 2 (Athletic)

Eligibility Criteria

• Age: 20 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age: Between 20-50 years old
• Gender: Male or female
• Health status: Good general health
• Physical activity: Normally Active Individuals or Regularly engaging in jumping sports activities such as volleyball, marathon, or tennis, or not engaging in such activities

You may not qualify if:

• Individuals who cannot tolerate whole-body vibration
• Individuals with a history of neuromuscular disease
• Individuals with a history of skeletal disease

Sponsors & Collaborators

• Eser Kalaoglu: lead

Study Sites (1)

Istanbul Physical Medicine Rehabilitation Training and Research Hospital

Istanbul, 31180, Turkey (Türkiye)

Location

Related Publications (4)

• Yildirim MA, Topkara B, Aydin T, Paker N, Soy D, Coskun E, Ones K, Bardak A, Kesiktas N, Ozyurt MG, Celik B, Onder B, Kilic A, Kucuk HC, Karacan I, Turker KS. Exploring the receptor origin of vibration-induced reflexes. Spinal Cord. 2020 Jun;58(6):716-723. doi: 10.1038/s41393-020-0419-5. Epub 2020 Jan 15.

  PMID: 31942042 BACKGROUND

• Karacan I, Turker KS. Exploring neuronal mechanisms of osteosarcopenia in older adults. J Physiol. 2024 Aug 9. doi: 10.1113/JP285666. Online ahead of print.

  PMID: 39119811 BACKGROUND

• Ishikawa S, Kim Y, Kang M, Morgan DW. Effects of weight-bearing exercise on bone health in girls: a meta-analysis. Sports Med. 2013 Sep;43(9):875-92. doi: 10.1007/s40279-013-0060-y.

  PMID: 23754172 BACKGROUND

• Zhang L, Miramini S, Richardson M, Ebeling P, Little D, Yang Y, Huang Z. Computational modelling of bone fracture healing under partial weight-bearing exercise. Med Eng Phys. 2017 Apr;42:65-72. doi: 10.1016/j.medengphy.2017.01.025. Epub 2017 Feb 22.

  PMID: 28236603 BACKGROUND

Study Officials

• İlhan Karacan, Prof.

  Istanbul Physical Medicine Rehabilitation Training and Research Hospital

  STUDY DIRECTOR

• Eser Kalaoglu, M.D.

  Istanbul Physical Medicine Rehabilitation Training and Research Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal Investigator

Model Details: This study employs a quasi-experimental design. Participants will be divided into two groups based on their physical activity level: Group 1 (Normally Active Individuals), who engage in typical daily activities without regular sports participation, and Group 2 (Athletic Individuals), who regularly engage in athletic activities.

Study Record Dates

• First Submitted: November 19, 2024
• First Posted: December 2, 2024
• Study Start: December 1, 2024
• Primary Completion: January 1, 2025
• Study Completion: January 15, 2025
• Last Updated: April 16, 2025

Record last verified: 2024-11

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)