NCT06705907

Brief Summary

The goal of this study is to test how well two group interventions work for middle-school children with Autism Spectrum Disorder (ASD). One of the interventions focuses on teaching parents and adolescent skills to help improve their social functioning and the other focuses on teaching parents and adolescents skills to improve organization, planning, and study skills. Eligible participants will be randomly (like a coin flip) assigned to attend one of the two interventions.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
224

participants targeted

Target at P75+ for not_applicable

Timeline
40mo left

Started Dec 2024

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress31%
Dec 2024Aug 2029

First Submitted

Initial submission to the registry

November 23, 2024

Completed
3 days until next milestone

First Posted

Study publicly available on registry

November 26, 2024

Completed
5 days until next milestone

Study Start

First participant enrolled

December 1, 2024

Completed
4.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 31, 2029

Expected
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

August 31, 2029

Last Updated

March 17, 2026

Status Verified

March 1, 2026

Enrollment Period

4.5 years

First QC Date

November 23, 2024

Last Update Submit

March 16, 2026

Conditions

Keywords

social skillsexecutive functionsacademic achievementmiddle school

Outcome Measures

Primary Outcomes (3)

  • Behavior Rating Inventory of Executive Functioning, 2nd Edition

    The BRIEF-2 assesses real-world EF behaviors in the home and school environments. The T-scores range from 30:99 with higher scores being worse.

    From enrollment to the end of treatment at 8 weeks.

  • Homework Problems Checklist

    The HPC assesses Homework Completion and Homework Management. Scores for Homework Completion range from 0 to 36 and for Homework Management from 0 to 21. Lower scores are better.

    From enrollment to end of treatment at 8 weeks.

  • Academic Performance Rating Scale

    The teacher-completed APRS assesses how well the adolescent is performing academically with 3 subscales (Academic Success, Academic Productivity, and Impulse Control). The two scores to be used in the current study include the Academic Success score which ranges from 7 to 35, while the Academic Productivity score ranges from 12 to 60. Higher scores are better.

    From enrollment to end of treatment at 8 weeks.

Secondary Outcomes (3)

  • Children's Organizational Skills Scale

    From enrollment to the end of treatment at 8 weeks.

  • Weekly Calendar Planning Activity

    From enrollment to the end of treatment at 8 weeks.

  • Social Skills Assessment (TRIAD)

    From enrollment to the end of treatment at 8 weeks.

Study Arms (2)

Achieving Independence & Mastery in School (AIMS)

EXPERIMENTAL

AIMS targets executive functioning skills using evidence-based strategies for youth with ASD to promote increased independence related to academics. Each session involves a review of a real world practice assignment and a didactic component illustrating key concepts followed by an in-session practice of the key concepts and strategies with coaching from a therapist. A behavior agreement is used to identify specific goals for adolescents to work on in collaboration with their caregivers and specific rewards earned for meeting their goals. Adolescents are assigned a real world practice assignment each session that consists of additional practice of strategies to further build and generalize skills between sessions.

Behavioral: Achieving Independence and Mastery in School (AIMS)

Building Essential Social Skills for Teens (BESST)

ACTIVE COMPARATOR

BESST targets social skills using evidence-based strategies and includes sessions related to starting, joining, maintaining, and ending conversations and making, maintaining, and deepening friendships. Each skill will be introduced in a didactic lesson which includes modeling of the targeted skill by a therapist. Adolescents will role-play new skills during the session before receiving a homework assignment to practice the skill at home. Caregivers will receive training in social-communication difficulties in ASD and suggestions for supporting development of these skills. The sessions are specifically focused on generalizing newly learned skills to both home and school.

Behavioral: Building Essential Social Skills for Teens (BESST)

Interventions

Intervention targeting academic executive functioning

Also known as: AIMS
Achieving Independence & Mastery in School (AIMS)

Intervention targeting social skills

Also known as: BESST
Building Essential Social Skills for Teens (BESST)

Eligibility Criteria

Age10 Years - 15 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17)

You may qualify if:

  • Diagnosis of autism
  • No intellectual disability
  • Problems with organization, materials management, and planning and prioritization
  • Problems with social skills
  • Fully included in middle school
  • Stable medication and behavioral treatment regime

You may not qualify if:

  • Home schooled
  • Severe co-occurring psychopathology (e.g., aggression, suicidal)
  • Non English-speaking

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Cincinnati Children's Hospital

Cincinnati, Ohio, 45229, United States

RECRUITING

MeSH Terms

Conditions

Autistic DisorderAutism Spectrum DisorderSocial Skills

Interventions

Schools

Condition Hierarchy (Ancestors)

Child Development Disorders, PervasiveNeurodevelopmental DisordersMental DisordersSocial BehaviorBehavior

Intervention Hierarchy (Ancestors)

Non-Medical Public and Private Facilities

Study Officials

  • Leanne Tamm, Ph.D.

    Children's Hospital Medical Center, Cincinnati

    PRINCIPAL INVESTIGATOR
  • Amie Duncan, Ph.D.

    Children's Hospital Medical Center, Cincinnati

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Leanne Tamm, Ph.D.

CONTACT

Amie Duncan, Ph.D.

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 23, 2024

First Posted

November 26, 2024

Study Start

December 1, 2024

Primary Completion (Estimated)

May 31, 2029

Study Completion (Estimated)

August 31, 2029

Last Updated

March 17, 2026

Record last verified: 2026-03

Data Sharing

IPD Sharing
Will share

All collected IPD will be entered into NIMH's Data Archive (NDA) in order to contribute to the advancement of research on individuals with ASD. In our Background History Form, we will collect the prerequisite information (i.e., specific information such as legal name, date of birth, sex, and city of birth) needed to generate a GUID. Informed consent documents will inform participants that their data will be entered into NDA.

Shared Documents
STUDY PROTOCOL, ICF
Time Frame
August 31, 2029
Access Criteria
Investigators interested in using the data obtained in this study will be directed to obtain the data from NDA. Other materials can be obtained from the study principal investigators upon reasonable request.

Locations