Exercise Timing on the Morning Blood Pressure Surge

NCT06702930 | Completed

• 1 other identifier: 19-07-002
• Study Type: interventional
• Target: 31
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial was to assess the effects of morning vs. evening high-intensity interval exercise on the magnitude of the morning blood pressure surge in young healthy adults. The main questions it aimed to answer were:

• Does the timing of high-intensity interval exercise modulate the magnitude of the morning blood pressure surge?
• Do sex differences exist? Participants came in and completed a bout of high-intensity interval exercise in the morning (8-10 am) and evening (5-7 pm) as well as a no exercise control, and ambulatory blood pressure was assessed for 24 hours afterwards.

Conditions

Post-Exercise Hypotension; Ambulatory Blood Pressure Monitoring; High-intensity Interval Exercise

Keywords

Ambulatory blood pressure monitoring; Morning blood pressure surge; High-intensity interval exercise; Post-exercise hypotension

Outcome Measures

Primary Outcomes (1)

• Morning blood pressure surge

  The difference between morning blood pressure (the mean of the 4 blood pressure readings after awakening) and sleep-trough blood pressure (the mean of the lowest blood pressure during sleep and two adjacent blood pressure readings).

  Through study completion, an average of 4 weeks.

Secondary Outcomes (1)

• Nighttime blood pressure dip

  Through study completion, an average of 4 weeks.

Study Arms (3)

Control

NO INTERVENTION

No exercise was performed and ambulatory blood pressure was assessed for 24 hours.

Morning high-intensity interval exercise

EXPERIMENTAL

High-intensity interval exercise was performed between 8-10 am and ambulatory blood pressure was assessed for 24 hours after.

Other: Morning high-intensity interval exercise

Evening high-intensity interval exercise

EXPERIMENTAL

High-intensity interval exercise was performed between 5-7 pm and ambulatory blood pressure was assessed for 24 hours after.

Other: Evening high-intensity interval exercise

Interventions

Morning high-intensity interval exercise OTHER

High-intensity interval exercise was performed between 8-10 am

Morning high-intensity interval exercise

Evening high-intensity interval exercise OTHER

High-intensity interval exercise was performed between 5-7 pm

Evening high-intensity interval exercise

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Between 18-50 years of age.
• No history of known disease.
• None smokers.
• No use of chronic medications other than oral contraceptives.

You may not qualify if:

• \<18 years of age.
• \>50 years of age.
• Cardiovascular disease.
• Metabolic disease.
• History of smoking (within the past 3 months).
• Chronic medications (other than oral contraceptives).

Sponsors & Collaborators

• University of Guelph: lead

Study Sites (1)

University of Guelph

Guelph, Ontario, N1G 2W1, Canada

Location

Related Publications (1)

• Bommarito J, Millar PJ. The effects of morning versus evening high-intensity interval exercise on the magnitude of the morning blood pressure surge. Appl Physiol Nutr Metab. 2025 Jan 1;50:1-11. doi: 10.1139/apnm-2024-0449.

  PMID: 39689295 DERIVED

MeSH Terms

Conditions

Post-Exercise Hypotension

Condition Hierarchy (Ancestors)

Orthostatic Intolerance; Primary Dysautonomias; Autonomic Nervous System Diseases; Nervous System Diseases; Hypotension; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Julian Bommarito, MSc

  University of Guelph

  STUDY DIRECTOR

• Philip Millar, PhD

  University of Guelph

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: November 19, 2024
• First Posted: November 25, 2024
• Study Start: January 28, 2020
• Primary Completion: June 8, 2023
• Study Completion: June 8, 2023
• Last Updated: November 27, 2024

Record last verified: 2024-11

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: After publication; unending.
• Access Criteria: Investigators whose proposed use of the data has been approved by an independent review committee ("learned intermediary") identified for this purpose.

Locations

CA (1)