The Effects of Dietary Salt on Post-exercise Hypotension

NCT03565653 | Completed

• 1 other identifier: 1085139
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The new American Heart Association (AHA) blood pressure guidelines are expected to raise the prevalence of high blood pressure to \~46% in the United States. One recommendation for lowering blood pressure is aerobic exercise, which produces a period of lowered blood pressure (post-exercise hypotension; PEH) that lasts up to 24 hours. It is believed that PEH may be responsible for the observations of lowered blood pressure following initiation of exercise. However, most Americans eat too much salt, which expands plasma volume and may prevent PEH, rending aerobic exercise ineffective in improving blood pressure status.

Conditions

Blood Pressure; Post-Exercise Hypotension

Outcome Measures

Primary Outcomes (1)

• Post-exercise hypotension

  Change in mean arterial pressure from pre- to post-exercise

  24 hours following exercise

Secondary Outcomes (1)

• Blood pressure reactivity

  10th day of high salt diet

Study Arms (2)

High dietary salt

EXPERIMENTAL

For 10 days each, participants will be asked to eat a recommended sodium diets (2300 mg Na+/d) while taking unmarked pills containing uniodized table salt. On the 10th day, participants will report to the lab to complete 60 minutes of cycling exercise. Following exercise, participants will rest for 60 minutes while undergoing serial blood pressure measurements. Participants will then be outfitted with ambulatory blood pressure cuffs for assessment of blood pressure over the following 24 hours.

Other: High dietary salt

Placebo

EXPERIMENTAL

For 10 days each, participants will be asked to eat a recommended sodium diets (2300 mg Na+/d) while taking unmarked pills containing a placebo (dextrose). Participants will complete both interventions in random order. On the 10th day, participants will report to the lab to complete 60 minutes of cycling exercise. Following exercise, participants will rest for 60 minutes while undergoing serial blood pressure measurements. Participants will then be outfitted with ambulatory blood pressure cuffs for assessment of blood pressure over the following 24 hours.

Other: Placebo

Interventions

High dietary salt OTHER

\~4,000 mg Na+/day

High dietary salt

Placebo OTHER

dextrose

Placebo

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Recreationally active

You may not qualify if:

• high blood pressure (\>140/90 mmHg)
• history of cardiovascular disease
• history of cancer
• history of diabetes
• history of kidney disease
• obesity (BMI \> 30 kg/m2)
• smoking or tobacco use
• current pregnancy
• nursing mothers
• communication barriers

Sponsors & Collaborators

• University of Delaware: lead

Study Sites (1)

Department of Kinesiology and Applied Physiology, University of Delaware

Newark, Delaware, 19713, United States

Location

MeSH Terms

Conditions

Post-Exercise Hypotension

Condition Hierarchy (Ancestors)

Orthostatic Intolerance; Primary Dysautonomias; Autonomic Nervous System Diseases; Nervous System Diseases; Hypotension; Vascular Diseases; Cardiovascular Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: June 11, 2018
• First Posted: June 21, 2018
• Study Start: May 1, 2018
• Primary Completion: June 30, 2019
• Study Completion: July 1, 2019
• Last Updated: October 1, 2019

Record last verified: 2019-09

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)