Mechanical Thrombectomy in the Middle East and North Africa: Interim Results from the MEMENTO Registry

NCT06702787 | Enrolling By Invitation DMC

• 1 other identifier: MENASINO1002
• Study Type: observational
• Target: 1,500
• Locations: 1 country
• Sites: 1

Brief Summary

The MEMENTO (MEchanical thrMobectomy NETwork for MENA TOgether) Registry is a multicenter, prospective observational study aiming to evaluate the effectiveness, safety, and cost-effectiveness of mechanical thrombectomy (MT) in patients with acute ischemic stroke (AIS) due to large vessel occlusions (LVO) in the Middle East and North Africa (MENA) region. This interim analysis reports on the first 499 patients enrolled, assessing clinical outcomes, procedural details, and economic implications.

Conditions

Stroke; Stroke Acute; Endovascular Procedures; Large Vessel Occlusion

Keywords

Mechanical Thrombectomy; Acute Ischemic; Stroke Large Vessel Occlusion; Middle East and North Africa MENA Region; Endovascular Treatment; Cerebral Infarction; Brain Ischemia; Stroke Management; Reperfusion Therapy; Neurointervention Cerebrovascular

Outcome Measures

Primary Outcomes (1)

• Functional Independence at 90 Days

  Description: Proportion of patients achieving a modified Rankin Scale (mRS) score of 0-2 at 90 days post-procedure.

  90 days post-procedure

Secondary Outcomes (6)

• Proportion of Patients Achieving TICI Score ≥2b After MT

  Immediately post-procedure

• Improvement in NIHSS Score from Baseline to 24 Hours and at Follow-up

  Baseline, 24 hours, and up to 90 days

• Symptomatic Intracerebral Hemorrhage (sICH) Rate

  Within 7 days post-procedure

• All-Cause Mortality at 90 Days

  90 days post-procedure

• Complication Rate

  Immediately post-procedure up to 7 days

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Consecutive patients presenting with acute ischemic stroke due to LVO or MeVO at participating centers in the MENA region, who received MT as part of standard clinical practice.

You may qualify if:

• Adults aged 18 years and older (no upper age limit). Diagnosed with acute ischemic stroke due to confirmed large vessel occlusion (LVO) or medium vessel occlusion (MeVO).
• Underwent mechanical thrombectomy (MT) with or without prior intravenous thrombolysis (IV tPA).
• Pre-stroke modified Rankin Scale (mRS) score of 0-5. Consent to participate in the registry (by patient or legal representative).

You may not qualify if:

• Absence of confirmed LVO or MeVO. Pre-stroke mRS score of 6. Known severe comorbid conditions precluding MT. Inability to obtain informed consent. Patients not treated with MT.

Sponsors & Collaborators

• Middle East North Africa Stroke and Interventional Neurotherapies Organization: lead

Study Sites (1)

Alexandria University Stroke network

Alexandria, Alexandria Governorate, Egypt

Location

MeSH Terms

Conditions

Stroke; Cerebral Infarction; Brain Ischemia

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Brain Infarction; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Study Officials

• ossama yassin MANSOUR, MD, PhD,

  Alexandria University

  PRINCIPAL INVESTIGATOR

• farouk Hassan, MD,Phd

  cairo university, Egypt

  PRINCIPAL INVESTIGATOR

• Atila Oscan Ozdimar, MD, PhD

  Eskisehir Osmangazi University

  PRINCIPAL INVESTIGATOR

• Syed Irteza Hussain, MD

  Cleveland Clinic Abu Dhabi

  PRINCIPAL INVESTIGATOR

• Faisal Alghamdi, MD

  King Abdullah Medical City

  PRINCIPAL INVESTIGATOR

• Nadia Hammami, MD

  institut National de Neurologie

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 90 Days
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 14, 2024
• First Posted: November 25, 2024
• Study Start: March 11, 2022
• Primary Completion: April 11, 2025
• Study Completion: September 11, 2025
• Last Updated: November 25, 2024

Record last verified: 2024-11

Locations

EG (1)