The Application of Ultrasonic Measurement of Optic Nerve Sheath Diameter in Liposuction Surgery

NCT06685952 | Completed

• 1 other identifier: ZX2024310
• Study Type: observational
• Target: 55
• Locations: 1 country
• Sites: 1

Brief Summary

The main purpose of this study is to investigate the effect of changes in Optic Nerve Sheath Diameter (ONSD) measured at different operating position during Liposuction Surgery. Optic nerve sheath diameter (ONSD) has been shown to be a noninvasive indicator for monitoring intracranial pressure changes. The use of anesthetic drugs will reduce the intracranial pressure. However, prone position and large fluid infusion can still lead to increased intracranial pressure. The investigators hypothesized that during sedation and analgesia anesthesia, patients in prone position had higher ONSD.

Conditions

Optic Nerve Sheath Diameter

Keywords

Optic nerve sheath diameter; Sedation and analgesia anesthesia; Liposuction surgery

Outcome Measures

Primary Outcomes (1)

• Optic nerve sheath diameter

  Optic nerve sheath diameter under Ultrasonic measurement

  Enter the operating room, 30min and 60min after sedative AND analgesic anaesthesia, end of surgery

Secondary Outcomes (16)

• Carotid artery flow rate

  Enter the operating room, 30min and 60min after sedative AND analgesic anaesthesia, end of surgery

• Carotid artery width

  Enter the operating room, 30min and 60min after sedative AND analgesic anaesthesia, end of surgery

• Bispectral index (BIS)

  30min and 60min after sedative AND analgesic anaesthesia, end of surgery

• OAA/S score

  30min and 60min after sedative AND analgesic anaesthesia, end of surgery

• Liposuction swelling fluid input

  30min and 60min after sedative AND analgesic anaesthesia, end of surgery

Study Arms (2)

Prone position group

Sedation and analgesia anesthesia will be administered after the prone position. All patients will receive standardized sedation and analgesia anesthesia with 1ug/kg sufentanil，1ug/kg/h dexmedetomidine，1mg/h midazolam，0.05-0.1ug/kg/min remifentanil. And adjust the drug speed according to the patient's respiratory rate, BIS changes. Optic nerve sheath diameter (ONSD), carotid artery flow rate, Bispectral index (BIS), liposuction swelling fluid input, infusion volume, end-expiratory carbon dioxide, mean arterial pressure, heart rate, peripheral oxygen saturation, body temperature and respiratory rate will be measured at four time points respectively.

Supine group

Sedation and analgesia anesthesia will be administered after the supine position. All patients will receive standardized sedation and analgesia anesthesia with 1ug/kg sufentanil，1ug/kg/h dexmedetomidine，1mg/h midazolam，0.05-0.1ug/kg/min remifentanil. And adjust the drug speed according to the patient's respiratory rate, BIS changes. Optic nerve sheath diameter (ONSD), carotid artery flow rate, Bispectral index (BIS), liposuction swelling fluid input, infusion volume, end-expiratory carbon dioxide, mean arterial pressure, heart rate, peripheral oxygen saturation, body temperature and respiratory rate will be measured at four time points respectively.

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Female patients who will undergo liposuction surgery under sedation and sedative anesthesia. Fat suction areas can be the abdomen, lower back, limbs and other parts.

You may qualify if:

• Patients aged 18-50 years, undergoing liposuction surgery.
• American Society of Anesthesiologists (ASA) physical status Ⅰ and Ⅱ.
• Voluntary participation and signed an informed consent form.

You may not qualify if:

• Uncontrolled hypertension, diabetes.
• High nearsightedness or farsightedness, recent eye surgery, and other conditions in which ONSD cannot be measured.
• Moderate to severe obstructive sleep apnea syndrome was present before surgery.
• History of severe mental or neurological diseases, drug or psychotropic drug abuse.
• Cognitive dysfunction or inability to communicate.

Sponsors & Collaborators

• The Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College: lead

Study Sites (1)

Xu Wenli

Beijing, Beijing Municipality, 100144, China

Location

Study Officials

• Dong Yang

  Plastic Surgery Hospital, Chinese Academy of Medical Sciences and PekingUnion Medical College

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Attending physician

Study Record Dates

• First Submitted: November 7, 2024
• First Posted: November 13, 2024
• Study Start: November 19, 2024
• Primary Completion: May 25, 2025
• Study Completion: May 26, 2025
• Last Updated: September 30, 2025

Record last verified: 2025-09

Locations

CN (1)