The Effects of Lateral 45° Downward Position on the Optic Nerve Sheath Diameter

NCT05185908 | Completed

• 1 other identifier: OpticNerveSheathIU
• Study Type: observational
• Target: 26
• Locations: 0 countries
• Sites: N/A

Brief Summary

Trendelenburg position and carbon dioxide (CO2) pneumoperitoneum are in association with increased intracranial pressure (ICP) reflected by the optic nerve sheath diameter (ONSD). Measurement of ONSD by ultrasound (US) guidance can be used in the diagnosis of ICP. The investigators interrogated the effects of lateral 45° downward position and CO2 insufflation on ONSD in patients undergoing laparoscopic transperitoneal nephrectomy.

Conditions

Optic Nerve Sheath Diameter

Keywords

Carbondioxide pneumoperitoneum; Optic nerve; Nephrectomy

Outcome Measures

Primary Outcomes (1)

• optic nerve sheath diameter

  Measurement of optic nerve sheath diameter by ultrasound (US) guidance can be used in the diagnosis of increased intracranial pressure (ICP).

  up to 24 hours

Secondary Outcomes (2)

• Respiratory parameters

  up to 24 hours

• Hemodynamic parameters

  up to 24 hours

Study Arms (1)

Group 1

The patients undergoing laparoscopic transperitoneal nephrectomy.

Procedure: Measurement of the optic nerve sheath diameter by ultrasound-guidance.

Interventions

Measurement of the optic nerve sheath diameter by ultrasound-guidance. PROCEDURE

Measurement of the optic nerve sheath diameter (ONSD) by ultrasound guidance can be used in the diagnosis of increased ICP. The investigators interrogated the effects of lateral 45° downward position and CO2 insufflation on ONSD in patients undergoing laparoscopic transperitoneal nephrectomy.

Group 1

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Twenty-six patients who have undergone laparoscopic transperitoneal nephrectomy in the period of December 2016 and February 2017 were included in this study.

You may qualify if:

• All patients older than 18 years who have undergone laparoscopic transperitoneal nephrectomy.

You may not qualify if:

• Those who have neurological and cerebrovascular disease.

Sponsors & Collaborators

• Istanbul University: lead

Related Publications (4)

• Verdonck P, Kalmar AF, Suy K, Geeraerts T, Vercauteren M, Mottrie A, De Wolf AM, Hendrickx JF. Optic nerve sheath diameter remains constant during robot assisted laparoscopic radical prostatectomy. PLoS One. 2014 Nov 4;9(11):e111916. doi: 10.1371/journal.pone.0111916. eCollection 2014.

  PMID: 25369152 BACKGROUND

• Chin JH, Seo H, Lee EH, Lee J, Hong JH, Hwang JH, Kim YK. Sonographic optic nerve sheath diameter as a surrogate measure for intracranial pressure in anesthetized patients in the Trendelenburg position. BMC Anesthesiol. 2015 Mar 31;15:43. doi: 10.1186/s12871-015-0025-9. eCollection 2015.

  PMID: 25861241 BACKGROUND

• Blecha S, Harth M, Schlachetzki F, Zeman F, Blecha C, Flora P, Burger M, Denzinger S, Graf BM, Helbig H, Pawlik MT. Changes in intraocular pressure and optic nerve sheath diameter in patients undergoing robotic-assisted laparoscopic prostatectomy in steep 45 degrees Trendelenburg position. BMC Anesthesiol. 2017 Mar 11;17(1):40. doi: 10.1186/s12871-017-0333-3.

  PMID: 28284189 BACKGROUND

• Atasever AG, Salviz EA, Senturk Ciftci H, Bingul ES, Sivrikoz N, Erdem S, Savran Karadeniz M. The Effects of Lateral 45 degrees Head-Down Position and Carbon Dioxide Pneumoperitoneum on the Optic Nerve Sheath Diameter in Patients Undergoing Laparoscopic Transperitoneal Nephrectomies: A Prospective Observational Study. J Laparoendosc Adv Surg Tech A. 2023 Feb;33(2):171-176. doi: 10.1089/lap.2022.0344. Epub 2022 Aug 25.

  PMID: 36036829 DERIVED

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: December 5, 2021
• First Posted: January 11, 2022
• Study Start: December 1, 2016
• Primary Completion: March 2, 2017
• Study Completion: January 1, 2019
• Last Updated: January 11, 2022

Record last verified: 2021-12

Data Sharing

• IPD Sharing: Will not share