Changes in Optic Nerve Sheath Diameter in Desflurane Based General Anesthesia During Laparoscopic Cholecystectomies

NCT06896604 | Completed

• 1 other identifier: FSMTRH-AR-MGO-01
• Study Type: observational
• Target: 64
• Locations: 1 country
• Sites: 1

Brief Summary

In this study, the investigators to observe the effects of different fresh gas flow rates, which are frequently used in general anesthesia practice, on optic nerve sheath diameter during laparoscopic cholecystectomy surgeries under general anesthesia with desflurane.

Conditions

Optic Nerve Sheath Diameter

Keywords

Low Fresh Gas Flow, Desflurane; Desflurane; Cholecystectomy, Laparoscopic; Spectroscopy, Near-Infrared; Optic Nerve Sheath Diameter Sonography

Outcome Measures

Primary Outcomes (1)

• Ultrasonographic Measurement of Optic Nerve Sheath Diameter for Observing Intracranial Pressure Increase

  Investigation of the Effects of Desflurane Administration with Different Fresh Gas Flow Rates on Optic Nerve Sheath Diameter

  through study completion, an average of 2 months

Secondary Outcomes (1)

• Monitoring Cerebral Perfusion Using Near-Infrared Spectroscopy

  through study completion, an average of 2 months

Study Arms (2)

low flow anesthesia with desflurane

After standard induction procedures, the fresh gas flow was reduced to 1 L/min during the maintenance phase of inhalation anesthesia with desflurane.

Device: Ocular Ultrasonography for measuring Optic Nerve Sheath Diameter

high flow anesthesia with desflurane

After standard induction procedures, the fresh gas flow was set to 3 L/min during the maintenance phase of inhalation anesthesia with desflurane.

Device: Ocular Ultrasonography for measuring Optic Nerve Sheath Diameter

Interventions

Ocular Ultrasonography for measuring Optic Nerve Sheath Diameter DEVICE

In the study, the investigators measured the optic nerve sheath diameter to observe its effects on intracranial pressure and used ocular ultrasonography for this measurement.

high flow anesthesia with desflurane; low flow anesthesia with desflurane

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients aged 18-65 years with an American Society of Anesthesiologists (ASA) physical status classification of I-III and a body mass index (BMI) \< 35 kg/m², undergoing elective laparoscopic cholecystectomy under general anesthesia.

You may qualify if:

• Patients Undergoing Elective Laparoscopic Cholecystectomy Under General Anesthesia
• Patients aged 18-65 years with an American Society of Anesthesiologists (ASA) physical status classification of I-III and a body mass index (BMI) \< 35 kg/m²
• Patients who have provided informed consent

You may not qualify if:

• Patients under 18 or over 65 years old, those classified as ASA IV-V, or with a BMI ≥ 35 kg/m²
• Patients with conditions that may lead to increased intracranial pressure (e.g., intracranial mass, aneurysm, head trauma), a history of intracranial surgery, previous ischemic or hemorrhagic stroke, or neurological diseases
• Patients with a history of glaucoma or cataract surgery
• Patients undergoing emergency surgical procedures
• Patients with severe cardiac, renal, pulmonary, or hepatic failure
• Patients who do not provide informed consent

Sponsors & Collaborators

• Fatih Sultan Mehmet Training and Research Hospital: lead

Study Sites (1)

Fatih Sultan Mehmet Training and Research Hospital

Istanbul, Atasehir, 34752, Turkey (Türkiye)

Location

Related Publications (8)

• Geeraerts T, Merceron S, Benhamou D, Vigue B, Duranteau J. Non-invasive assessment of intracranial pressure using ocular sonography in neurocritical care patients. Intensive Care Med. 2008 Nov;34(11):2062-7. doi: 10.1007/s00134-008-1149-x. Epub 2008 May 29.

  PMID: 18509619 RESULT

• Akbas S, Ozkan AS. Comparison of effects of low-flow and normal-flow anesthesia on cerebral oxygenation and bispectral index in morbidly obese patients undergoing laparoscopic sleeve gastrectomy: a prospective, randomized clinical trial. Wideochir Inne Tech Maloinwazyjne. 2019 Jan;14(1):19-26. doi: 10.5114/wiitm.2018.77265. Epub 2018 Jul 24.

  PMID: 30766625 RESULT

• Choi ES, Jeon YT, Sohn HM, Kim DW, Choi SJ, In CB. Comparison of the effects of desflurane and total intravenous anesthesia on the optic nerve sheath diameter in robot assisted laparoscopic radical prostatectomy: A randomized controlled trial. Medicine (Baltimore). 2018 Oct;97(41):e12772. doi: 10.1097/MD.0000000000012772.

  PMID: 30313092 RESULT

• Oterkus M, Donmez I, Nadir AH, Rencuzogullari I, Karabag Y, Binnetoglu K. The effect of low flow anesthesia on hemodynamic and peripheral oxygenation parameters in obesity surgery. Saudi Med J. 2021 Mar;42(3):264-269. doi: 10.15537/smj.2021.42.3.20200575.

  PMID: 33632904 RESULT

• Tekin EA, Gultop F, Baskurt NA. Minimal and normal-flow general anesthesia in patients undergoing surgery in prone position: impact on hemodynamics and regional cerebral oxygenation. Acta Cir Bras. 2023 Mar 24;38:e380523. doi: 10.1590/acb380523. eCollection 2023.

  PMID: 36995818 RESULT

• Bingol Tanriverdi T, Tercan M, Gusun Halitoglu A, Kaya A, Patmano G. Comparison of the Effects of Low-flow and Normal-flow Desflurane Anaesthesia on Inflammatory Parameters in Patients Undergoing Laparoscopic Cholecystectomy. Turk J Anaesthesiol Reanim. 2021 Feb;49(1):18-24. doi: 10.5152/TJAR.2020.30. Epub 2020 Nov 30.

  PMID: 33718901 RESULT

• Bedforth NM, Hardman JG, Nathanson MH. Cerebral hemodynamic response to the introduction of desflurane: A comparison with sevoflurane. Anesth Analg. 2000 Jul;91(1):152-5. doi: 10.1097/00000539-200007000-00028.

  PMID: 10866903 RESULT

• Jiang Z, Wu Y, Liang F, Jian M, Liu H, Mei H, Han R. Brain relaxation using desflurane anesthesia and total intravenous anesthesia in patients undergoing craniotomy for supratentorial tumors: a randomized controlled study. BMC Anesthesiol. 2023 Jan 10;23(1):15. doi: 10.1186/s12871-023-01970-z.

  PMID: 36624384 RESULT

Study Officials

• Oznur Demiroluk, As Prof

  Fatih Sultan Mehmet Training and Research Hospital

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: resident doctor

Study Record Dates

• First Submitted: March 18, 2025
• First Posted: March 26, 2025
• Study Start: February 1, 2025
• Primary Completion: April 1, 2025
• Study Completion: April 15, 2025
• Last Updated: April 16, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)