Skeletal Muscle Myokine Response to Acute Eccentric Exercise
1 other identifier
interventional
12
1 country
1
Brief Summary
The purpose of this study is to evaluate the acute local skeletal muscle inflammatory response to thigh muscle (quadriceps) eccentric muscle actions. Eccentric muscle actions occur when the muscle is lengthening as it contracts. This is a pilot project to assess the degree of inflammatory biomarkers, called myokines, that are released locally in skeletal muscle tissue after an acute bout of resistance-exercise using a resistance-exercise machine called an isokinetic dynamometer.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Nov 2024
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
July 5, 2024
CompletedFirst Posted
Study publicly available on registry
November 7, 2024
CompletedStudy Start
First participant enrolled
November 15, 2024
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 31, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2025
CompletedNovember 7, 2024
July 1, 2024
9 months
July 5, 2024
November 4, 2024
Conditions
Outcome Measures
Primary Outcomes (5)
Apelin
Concentration of apelin in skeletal muscle tissue
Baseline and 3-hours post-exercise
Fibroblast growth factor-21
Concentration of fibroblast growth factor-21 in skeletal muscle tissue
Baseline and 3-hours post-exercise
Irisin
Concentration of irisin in skeletal muscle tissue
Baseline and 3-hours post-exercise
Interleukin-6
Concentration of interleukin-6 in skeletal muscle tissue
Baseline and 3-hours post-exercise
Interleukin-15
Concentration of interleukin-15 in skeletal muscle tissue
Baseline and 3-hours post-exercise
Secondary Outcomes (5)
Body mass
Baseline
Body height
Baseline
Body mass index
Baseline
Fat mass
Baseline
Fat free mass
Baseline
Study Arms (1)
Eccentric Exercise
EXPERIMENTAL300 repetitions of isokinetic dynamometer eccentric knee extensions.
Interventions
Each participant will complete 300 repetitions of eccentric knee extensions using an isokinetic dynamometer after a baseline skeletal muscle biopsy is taken. Three hours following this, a second muscle biopsy will be taken to evaluate the changes in the dependent variables being measured (myokines).
Eligibility Criteria
You may qualify if:
- years old
- healthy
- recreationally active (\>/= 150 minutes of moderate to vigorous physical activity per week for at least the past three months)
You may not qualify if:
- "yes" answer to the Get Active Questionnaire which screens for health conditions that may affect exercise ability
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Applied Research Centre, Faculty of Kinesiology, University of Manitoba
Winnipeg, Manitoba, R3T2N2, Canada
Study Officials
- PRINCIPAL INVESTIGATOR
Stephen M Cornish, PhD
University of Manitoba
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
July 5, 2024
First Posted
November 7, 2024
Study Start
November 15, 2024
Primary Completion
July 31, 2025
Study Completion
November 1, 2025
Last Updated
November 7, 2024
Record last verified: 2024-07
Data Sharing
- IPD Sharing
- Will not share