Homocysteine and Coronary Artery Disease

NCT06675890 | Completed DMC

• 1 other identifier: 599/HEC/B&PSE/2021
• Study Type: observational
• Target: 381
• Locations: 1 country
• Sites: 1

Brief Summary

This study is aimed at correlating serum homocysteine level with coronary artery disease (CAD) and related in-hospital mortality. A cross section of patients from age 18 years and above will be studied for homocysteine level and analyzed for the above mentioned correlation. The study was approved by hospital ethical review board as mentioned. An informed written consent was obtained before the patients' recruitment.

Conditions

Coronary Arterial Disease (CAD)

Keywords

Coronary Artery Disease; Serum Homocysteine; In-hospital Mortality

Outcome Measures

Primary Outcomes (1)

• Homocysteine levels and its correlation with the type of coronary artery disease.

  Higher homocysteine levels in ST segment myocardial infarction (STEMI) and non ST segment myocardial infarction (NSTEMI) as compared to Angina.

  2 years

Secondary Outcomes (1)

• Risk factors for coronary artery disease

  2 years

Study Arms (1)

patients having coronary arterial disease.

patients with different types of coronary arterial disease and their homocysteine levels.

Diagnostic Test: serum homocysteine

Interventions

serum homocysteine DIAGNOSTIC_TEST

serum homocysteine is associated with atherosclerosis and vascular diseases.

patients having coronary arterial disease.

Eligibility Criteria

• Age: 25 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients of all ethnicities and both genders from 25 to 80 years with coronary artery disease.

You may qualify if:

• Coronary artery disease patients from age 25 years to 80 years.

You may not qualify if:

• Grade 4 chronic kidney disease patients
• Chronic liver disease patients
• Pregnant and lactating females
• Patients on vitamin supplements
• Patients with genetic homocysteine abnormalities

Sponsors & Collaborators

• Shaqra University: lead

Study Sites (1)

Hayatabad Medical Complex

Peshawar, KPK, 25000, Pakistan

Location

Related Publications (5)

• Hankey GJ, Eikelboom JW. Homocysteine and vascular disease. Lancet. 1999 Jul 31;354(9176):407-13. doi: 10.1016/S0140-6736(98)11058-9.

  PMID: 10437885 BACKGROUND

• Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med. 2000 Mar 23;342(12):836-43. doi: 10.1056/NEJM200003233421202.

  PMID: 10733371 BACKGROUND

• Roth GA, Mensah GA, Johnson CO, Addolorato G, Ammirati E, Baddour LM, Barengo NC, Beaton AZ, Benjamin EJ, Benziger CP, Bonny A, Brauer M, Brodmann M, Cahill TJ, Carapetis J, Catapano AL, Chugh SS, Cooper LT, Coresh J, Criqui M, DeCleene N, Eagle KA, Emmons-Bell S, Feigin VL, Fernandez-Sola J, Fowkes G, Gakidou E, Grundy SM, He FJ, Howard G, Hu F, Inker L, Karthikeyan G, Kassebaum N, Koroshetz W, Lavie C, Lloyd-Jones D, Lu HS, Mirijello A, Temesgen AM, Mokdad A, Moran AE, Muntner P, Narula J, Neal B, Ntsekhe M, Moraes de Oliveira G, Otto C, Owolabi M, Pratt M, Rajagopalan S, Reitsma M, Ribeiro ALP, Rigotti N, Rodgers A, Sable C, Shakil S, Sliwa-Hahnle K, Stark B, Sundstrom J, Timpel P, Tleyjeh IM, Valgimigli M, Vos T, Whelton PK, Yacoub M, Zuhlke L, Murray C, Fuster V; GBD-NHLBI-JACC Global Burden of Cardiovascular Diseases Writing Group. Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019: Update From the GBD 2019 Study. J Am Coll Cardiol. 2020 Dec 22;76(25):2982-3021. doi: 10.1016/j.jacc.2020.11.010.

  PMID: 33309175 BACKGROUND

• Wong ND. Epidemiological studies of CHD and the evolution of preventive cardiology. Nat Rev Cardiol. 2014 May;11(5):276-89. doi: 10.1038/nrcardio.2014.26. Epub 2014 Mar 25.

  PMID: 24663092 BACKGROUND

• Khan MA, Hashim MJ, Mustafa H, Baniyas MY, Al Suwaidi SKBM, AlKatheeri R, Alblooshi FMK, Almatrooshi MEAH, Alzaabi MEH, Al Darmaki RS, Lootah SNAH. Global Epidemiology of Ischemic Heart Disease: Results from the Global Burden of Disease Study. Cureus. 2020 Jul 23;12(7):e9349. doi: 10.7759/cureus.9349.

  PMID: 32742886 BACKGROUND

MeSH Terms

Conditions

Coronary Artery Disease

Condition Hierarchy (Ancestors)

Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

Study Officials

• Himayat Ullah, FCPS

  Shaqra University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Week
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor/Dr

Study Record Dates

• First Submitted: November 1, 2024
• First Posted: November 5, 2024
• Study Start: March 1, 2022
• Primary Completion: December 30, 2023
• Study Completion: December 30, 2023
• Last Updated: November 7, 2024

Record last verified: 2024-11

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)