Neutrophil-to-Lymphocyte and Platelet-to-lymphocyte Ratios as a Predictor Factors for Chronic Kidney Disease Progression

NCT06670599 | Not Yet Recruiting

• 1 other identifier: NLR & PLR in CKD.
• Study Type: observational
• Target: 200
• Locations: 0 countries
• Sites: N/A

Brief Summary

In this study, we aim to investigate whether NLR and PLR levels are associated with decline of kidney function in patients with CKD.

Conditions

CKD

Keywords

NLR & PLR in CKD

Outcome Measures

Primary Outcomes (1)

• Correlation between NLR, PLR and severity of CKD.

  Correlation between NLR, PLR and severity of CKD.

  Baseline

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Prevalence of Chronic Kidney disease (CKD) in 2017 was 7.1 million individuals globally and in Egypt was 106 patients per 1000 population estimated by (GBD) the Global Burden of Disease. In September 2021, about 10% of adult population is estimated to have CKD in the world, but the prevalence is higher in Egypt accounted for about 15-20% of adults.

You may qualify if:

• Patients diagnosed with CKD and their age range between 18-65 years old who will be admitted at AUH.

You may not qualify if:

• Pediatric patients aged below\< 18 or elderly patients aged above 65.
• Pregnant females.
• Patients with Diabetes Mellitus.
• Acute kidney injury (AKI).
• Patients with current infections.
• Patients who have any type of malignancy.
• Patients who have any type of multi-organ failure.
• CKD patients on dialysis

Sponsors & Collaborators

• Assiut University: lead

Related Publications (5)

• Gan W, Guan Q, Hu X, Zeng X, Shao D, Xu L, Xiao W, Mao H, Chen W. The association between platelet-lymphocyte ratio and the risk of all-cause mortality in chronic kidney disease: a systematic review and meta-analysis. Int Urol Nephrol. 2022 Nov;54(11):2959-2967. doi: 10.1007/s11255-022-03234-0. Epub 2022 May 17.

  PMID: 35581444 RESULT

• Altunoren O, Akkus G, Sezal DT, Ciftcioglu M, Guzel FB, Isiktas S, Torun GI, Uyan M, Sokmen MF, Sevim HA, Sarisik FN, Senel ME, Erken E, Gungor O. Does neutrophyl to lymphocyte ratio really predict chronic kidney disease progression? Int Urol Nephrol. 2019 Jan;51(1):129-137. doi: 10.1007/s11255-018-1994-7. Epub 2018 Oct 1.

  PMID: 30276600 RESULT

• Navarro JF, Milena FJ, Mora C, Leon C, Garcia J. Renal pro-inflammatory cytokine gene expression in diabetic nephropathy: effect of angiotensin-converting enzyme inhibition and pentoxifylline administration. Am J Nephrol. 2006;26(6):562-70. doi: 10.1159/000098004. Epub 2006 Dec 13.

  PMID: 17167242 RESULT

• Turkmen K, Guney I, Yerlikaya FH, Tonbul HZ. The relationship between neutrophil-to-lymphocyte ratio and inflammation in end-stage renal disease patients. Ren Fail. 2012;34(2):155-9. doi: 10.3109/0886022X.2011.641514. Epub 2011 Dec 16.

  PMID: 22172001 RESULT

• Manabe I. Chronic inflammation links cardiovascular, metabolic and renal diseases. Circ J. 2011;75(12):2739-48. doi: 10.1253/circj.cj-11-1184. Epub 2011 Nov 8.

  PMID: 22067929 RESULT

Central Study Contacts

Peter Said Ashamallah, Master

CONTACT

+201271131494; Petersaid9@gmail.com

Mohammad Hassan Mostafa

CONTACT

+201030430421; moh_has_mus@aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Doctor

Study Record Dates

• First Submitted: October 31, 2024
• First Posted: November 1, 2024
• Study Start: November 10, 2024
• Primary Completion: November 10, 2025
• Study Completion: November 10, 2025
• Last Updated: November 1, 2024

Record last verified: 2024-10

Data Sharing

• IPD Sharing: Will not share