Thyroid Dysfunction and Dyslipidemia in Patients With Chronic Kidney Diseases

NCT03277911 | Unknown DMC

• 1 other identifier: Clincal Pathology
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

Early diagnosis of thyroid and lipid disorders by regular screening, and treatment of such disorders in CKD patients may be highly beneficial to slow progression of CKD. The study will be conducted to investigate thyroid function and lipid profile in patients with chronic kidney disease.

Conditions

CKD

Outcome Measures

Primary Outcomes (2)

• The study will be conducted to investigate thyroid function in patients with chronic kidney disease

  serum urea, creatinine, , triiodothyronine \[T3\], free thyroxin \[T4\], thyroid stimulating hormones \[TSH\]

  one year

• The study will be conducted to investigate lipid profile in patients with chronic kidney disease

  serum urea, creatinine,high density lipoprotein \[HDL\] cholesterol, low density cholesterol, total cholesterol, triglyceride

  one year

Eligibility Criteria

• Age: 1 Year - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

The study will be conducted on 80 patients with chronic kidney disease at Assuit University hospital to investigate thyroid function and lipid profile in patients with CKD of stages (1-5) and 20 subjects as a normal control. A total of newly diagnosed and known CKD cases of stage 1-5 will be included in the study. Sample Size Calculation: * Group I: Controls-20 age and sex matched normal individuals. * Group II: Cases -40 patients with stage 1-3. * Group III: Cases -40 patients with stage 4 and 5

You may qualify if:

• Patients with CKD stage (1-5).
• Not known thyroid disorders.
• Not in lipid lowering agents.

You may not qualify if:

• Patients with known thyroid disorders, on medication affecting thyroid function and lipid lowering agents are excluded from the study.
• CKD patients who were or underwent previous dialysis.
• Nephrotic syndrome.
• Obesity.
• Patients on estrogens, corticosteroids, antithyroid drugs, dietary supplements.
• Pregnant woman

Sponsors & Collaborators

• Assiut University: lead

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident of clinical pathology department

Study Record Dates

• First Submitted: September 5, 2017
• First Posted: September 11, 2017
• Study Start: September 10, 2017
• Primary Completion: August 30, 2018
• Study Completion: August 30, 2019
• Last Updated: September 11, 2017

Record last verified: 2017-09