Correlation Between Preoperative Images of PPGL and Intraoperative Hemodynamics
Semiquantitative 131I-MIBG Scintigraphy Predicts Intraoperative Blood Pressure Fluctuation in Patients Undergoing Surgery for Pheochromocytoma and Paraganglioma
2 other identifiers
observational
159
1 country
1
Brief Summary
This is a retrospective observational cohort study involving patients with suspected PPGLs who underwent 131I-MIBG scanning and surgical treatment between January 2020 and April 2023. The objective is to evaluate the correlation between MIBG imaging score and intraoperative hemodynamic fluctuations.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Jan 2020
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 30, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
April 30, 2023
CompletedFirst Submitted
Initial submission to the registry
October 30, 2024
CompletedFirst Posted
Study publicly available on registry
November 1, 2024
CompletedNovember 1, 2024
April 1, 2023
3.3 years
October 30, 2024
October 30, 2024
Conditions
Outcome Measures
Primary Outcomes (1)
Difference of SBP ARV and MAP ARV in Different Groups
Mean arterial pressure (MAP) was calculated with the formula: MAP=1/3\*SBP+2/3\*DBP. ARV, which was defined as the average of absolute difference between successive BP values
Intraoperative systolic blood pressure (SBP) and diastolic blood pressure (DBP) were recorded automatically in a 5 min interval from the beginning to the end of surgery.
Interventions
Patients received thyroid blockade using solution of potassium iodide before the examination. After intravenous administration of 111 MBq of 131I-MIBG, whole body planar images were acquired at 24 hours (Day 1) and 48 hours (Day 2), respectively.
Eligibility Criteria
Patients with suspected PPGLs who received 131I-MIBG scintigraphy and were treated by surgery
You may qualify if:
- Patients with suspected PPGLs who received 131I-MIBG scintigraphy and were treated by surgery
You may not qualify if:
- \) surgery was performed more than 6 months after 131I-MIBG scintigraphy; 2) tumor located in bladder where radioactive urine would influence assessment of tumor; 3) tumor was not resected as a whole; 4) resected tumor was not PPGLs confirmed by pathology; 5) 131I-MIBG scintigraphy images or intraoperative BP was not available for assessment.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Peking union medical college hospital
Beijing, Beijing Municipality, 100730, China
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
October 30, 2024
First Posted
November 1, 2024
Study Start
January 1, 2020
Primary Completion
April 30, 2023
Study Completion
April 30, 2023
Last Updated
November 1, 2024
Record last verified: 2023-04