Erythropoietin Gel Effect on Dental Implant Stability

NCT06665451 | Recruiting

• 1 other identifier: Implant surface modification
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

• Achieving and maintaining long-term osseointegration for dental implants is a key objective in the field of dentistry. The success of osseointegration is influenced by the surface treatment applied to dental implants. Numerous coating techniques have been developed to improve and speed up osseointegration.
• The aim of the current study is to assess immediate dental implant stability coated with erythropoietin gel, both clinically and radiographically.
• Materials and Methods: We conducted a randomized controlled clinical trial.The sample will include patients demanding immediate implant treatment in the anterior maxilla . Patients will be randomly allocated into the two groups of the study. The group A will be treated with erythropoietin gel coated dental implant immediately after extraction of non restorable teeth in the anterior maxilla . Group B will be treated with non coated dental implant immediately after extraction of non restorable teeth in the anterior maxilla .
• The primary outcome variable will be implant stability and the secondary outcome will be crestal marginal bone level and bone density around implants. It will be measured at time of implant placement and reevaluated after 6-months .

Conditions

Osseointegration

Outcome Measures

Primary Outcomes (1)

• Change in implant stability

  Implant stability will be assessed by using ( AnyCheck - Implant Stability Tester ) Utilizes physical tapping technique and dumping capacity analysis to measure implant stability with precision

  Baseline and after 6 month

Secondary Outcomes (1)

• Change in marginal bone level and bone density around implants

  Baseline and after 6 month

Study Arms (2)

Test Group

EXPERIMENTAL

Patients with fresh extraction sockets in the anterior maxilla will be treated by immediate implant coated by erythropoietin gel .

Control group

ACTIVE COMPARATOR

Patients with fresh extraction sockets in the anterior maxilla will be treated by non coated immediate implant .

Other: Non coated dental implants

Interventions

Non coated dental implants OTHER

Patients with fresh extraction sockets in the anterior maxilla will be treated by non coated immediate implant .

Control group

Erythropoietin gel coated implants OTHER

Patients with fresh extraction sockets in the anterior maxilla will be treated by immediate implant coated by erythropoietin gel.

Eligibility Criteria

• Age: 20 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• All patients Should have nonrestorable teeth in the anterior maxilla indicated for extraction and seeking implant placement.
• Good general periodontal health and maintenance.

You may not qualify if:

• Heavy smokers who smoke more than ten cigarettes per day
• Acute infected socket
• Ant socket with wall defect.
• Pregnency
• Local or systemic conditions that will interfere with bone healing (uncontrolled diabetes mellitus or human immune deficiency virus infections, resonance therapy), bone disorders (hyperparathyroidism, osteoporosis, or Paget's disease.
• Patients who had subjected to intravenous and/or oral bisphosphonate therapy.

Sponsors & Collaborators

• Al-Azhar University: lead

Study Sites (1)

Faculty of dental medicine Al-Azhar university

Asyut, Asyut Governorate, 088, Egypt

RECRUITING

Study Officials

• Mohamed Alaa Lecturer of OMFS

  faculty of Dental medicine Al-Azhar University

  STUDY DIRECTOR

Central Study Contacts

Ahmed Mohsen Principle investigator

CONTACT

00201020994802; a7medmohsen453@gmail.com

Mohamed Mahjob Head of oral and maxillofacial surgery department

CONTACT

00201001544056

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principle investigator

Study Record Dates

• First Submitted: October 25, 2024
• First Posted: October 30, 2024
• Study Start: March 15, 2025
• Primary Completion: June 1, 2026
• Study Completion (Estimated): July 1, 2026
• Last Updated: May 18, 2026

Record last verified: 2026-05

Locations

EG (1)