Impact of Smoking Cessation Duration on Postoperative Complications in Lung Cancer Surgery

NCT06663020 | Active Not Recruiting

• 1 other identifier: B.30.2.ODM.0.20.08/19
• Study Type: observational
• Target: 248
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to investigate the relationship between the duration of smoking cessation before surgery and postoperative complications in lung cancer patients undergoing surgery. Lung cancer surgery patients who have recently quit smoking or are long-term nonsmokers will be evaluated to determine if the timing of smoking cessation impacts the risk of complications after surgery. By analyzing these factors, the study seeks to provide guidance on optimal smoking cessation timing to reduce postoperative risks.

Conditions

Smoking Cessation; Lung Cancer (NSCLC); Postoperative Complication

Keywords

lung cancer; smoking cessation; postoperative complication; thoracic surgery

Outcome Measures

Primary Outcomes (1)

• Incidence of Postoperative Complications Among Patients Following Lung Cancer Surgery Based on Duration of Smoking Cessation

  Postoperative complications will be assessed in patients who have undergone lung cancer surgery. Complications include both pulmonary (e.g., pneumonia, atelectasis, prolonged air leak) and non-pulmonary events (e.g., atrial fibrillation, wound infection) occurring within 30 days after surgery. The duration of smoking cessation prior to surgery will be recorded for each patient, and complications will be documented according to standard clinical criteria. This measure aims to determine if the length of smoking cessation impacts the likelihood and type of postoperative complications.

  From the day of surgery to 30 days postoperatively

Interventions

Smoking Cessation Duration BEHAVIORAL

Participants are categorized based on their smoking status and the duration since they quit smoking prior to lung cancer surgery. This observational study focuses on evaluating the relationship between the duration of smoking cessation (measured in days or weeks) and the incidence of postoperative complications. Smoking cessation duration is recorded for each participant to determine its impact on surgical outcomes.

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Participants will be selected from patients diagnosed with non-small cell lung cancer at the Ondokuz Mayis University Medical Faculty, Department of Thoracic Surgery. The study population consists of individuals scheduled for elective lung cancer surgery under general anesthesia, reflecting a clinical sample of patients who are typically managed within a tertiary care hospital setting.

You may qualify if:

• Patients aged between 18 and 80 years.
• Patients scheduled for elective surgery under general anesthesia due to NSCL.
• Patients classified as American Society of Anesthesiologists (ASA) I-III.
• Patients or their legally authorized representatives who have provided informed consent.

You may not qualify if:

• Patients with advanced chronic obstructive pulmonary disease (COPD) classified as GOLD Grade III-IV.
• Patients with severe and uncontrolled bronchial asthma.
• Patients with severe neuromuscular diseases or advanced thoracic deformity.
• Patients with severe heart disease classified as New York Heart Association (NYHA) Class III-IV.
• Patients with cognitive impairments.
• Patients undergoing emergency surgery.
• Pregnant patients.
• Patients with coagulopathy.
• Patients who have previously undergone video-assisted thoracoscopic surgery (VATS) and/or thoracotomy.
• Patients who died perioperatively.
• Patients or their legally authorized representatives who did not provide informed consent.

Sponsors & Collaborators

• Caner İşevi, MD: lead

Study Sites (1)

Ondokuz Mayis University Medical Faculty, Department of Thoracic Surgery

Samsun, Samsun, 55139, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Smoking Cessation; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Postoperative Complications

Condition Hierarchy (Ancestors)

Health Behavior; Behavior; Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases; Carcinoma, Bronchogenic; Bronchial Neoplasms; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 30 Days
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Thoracic Surgeon

Study Record Dates

• First Submitted: October 27, 2024
• First Posted: October 29, 2024
• Study Start: June 15, 2023
• Primary Completion: November 15, 2024
• Study Completion: December 15, 2025
• Last Updated: November 14, 2025

Record last verified: 2024-12

Locations

TU (1)