NCT05493254

Brief Summary

The purpose of this research study is to evaluate an electronic visit (e-visit) for smoking cessation. Participants will be randomly assigned to receive either the smoking cessation e-visit or not. The e-visit will look similar to an online questionnaire asking about smoking history, motivation to quit, and preferences for medications for quitting smoking. Participants may receive a prescription for a smoking cessation medication as an outcome of the e-visit, if randomized to the e-visit group, but there is no requirement to take any medication. This study consists of questionnaires and breath samples provided at 4 separate time points throughout the study. Participation in this study will take about 24 weeks.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
672

participants targeted

Target at P75+ for not_applicable

Timeline
8mo left

Started Aug 2022

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress86%
Aug 2022Dec 2026

First Submitted

Initial submission to the registry

August 5, 2022

Completed
4 days until next milestone

First Posted

Study publicly available on registry

August 9, 2022

Completed
22 days until next milestone

Study Start

First participant enrolled

August 31, 2022

Completed
4.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2026

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2026

Last Updated

March 5, 2026

Status Verified

March 1, 2026

Enrollment Period

4.3 years

First QC Date

August 5, 2022

Last Update Submit

March 3, 2026

Conditions

Outcome Measures

Primary Outcomes (18)

  • Number of participants who utilized smoking cessation treatment

    Number of participants who utilized smoking cessation treatment since last assessment.

    Month 1

  • Number of participants who utilized smoking cessation treatment

    Number of participants who utilized smoking cessation treatment since last assessment.

    Month 3

  • Number of participants who utilized smoking cessation treatment

    Number of participants who utilized smoking cessation treatment since last assessment.

    Month 6

  • Cigarettes smoking

    Cigarettes per day reduction greater than 50%

    Month 1

  • Cigarettes smoking

    Cigarettes per day reduction greater than 50%

    Month 3

  • Cigarettes smoking

    Cigarettes per day reduction greater than 50%

    Month 6

  • Quit attempts

    Quit attempts since last contact

    Month 1

  • Quit attempts

    Quit attempts since last contact

    Month 3

  • Quit attempts

    Quit attempts since last contact

    Month 6

  • Seven-day point prevalence abstinence

    Participant has not had a cigarette in the past 7 days

    Month 1

  • Seven-day point prevalence abstinence

    Participant has not had a cigarette in the past 7 days

    Month 3

  • Seven-day point prevalence abstinence

    Participant has not had a cigarette in the past 7 days

    Month 6

  • E-visit Acceptability

    The e-visit will be considered acceptable if the average score on the Acceptability of Intervention Measure (AIM) is greater than or equal to 4.

    Month 1

  • E-visit Acceptability

    The e-visit will be considered acceptable if the average score on the Acceptability of Intervention Measure (AIM) is greater than or equal to 4.

    Month 3

  • E-visit Acceptability

    The e-visit will be considered acceptable if the average score on the Acceptability of Intervention Measure (AIM) is greater than or equal to 4.

    Month 6

  • E-visit Adoption

    Patients prescribed a medication who obtain their medication

    Month 1

  • E-visit Adoption

    Patients prescribed a medication who obtain their medication

    Month 3

  • E-visit Adoption

    Patients prescribed a medication who obtain their medication

    Month 6

Study Arms (2)

Smoking cessation electronic visit (e-visit)

EXPERIMENTAL

This group will be sent 1) an invitation to complete an electronic visit (e-visit) focused on cigarette smoking and 2) an invitation to complete a follow-up e-visit one-month after the initial e-visit.

Behavioral: Smoking cessation e-visit

Treatment as usual (TAU)

ACTIVE COMPARATOR

This group will be provided information about the state quitline and about the importance of quitting smoking and it will be recommended that they contact their PCP to schedule a medical visit to discuss quitting smoking.

Behavioral: Treatment As Usual

Interventions

electronic visits (e-visits) for smoking cessation

Smoking cessation electronic visit (e-visit)

Information about the state quitline and about the importance of quitting smoking and a recommendation to contact one's PCP to schedule a medical visit to discuss quitting smoking.

Treatment as usual (TAU)

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • current smoking, defined as 1+ cigarettes/day, for 20+ days out of the last 30 for the last 6+ months
  • age 18+
  • enrolled in MyChart or willing to enroll
  • possess a valid e-mail address that is checked daily
  • owner of an iOS or Android smartphone to provide remote CO
  • have a valid mailing address
  • English fluency

You may not qualify if:

  • \) Use of an FDA-approved cessation medication in the last 7 days

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Medical University of South Carolina

Charleston, South Carolina, 29425, United States

RECRUITING

Related Publications (1)

  • Fahey MC, Wahlquist AE, Diaz VA, Player MS, Natale N, Sterba KR, Chen BK, Hermes EDA, Carpenter MJ, Dahne J. Rationale, design, and protocol for a hybrid type 1 effectiveness-implementation trial of a proactive smoking cessation electronic visit for scalable delivery via primary care: the E-STOP trial. BMC Prim Care. 2023 Nov 29;24(1):254. doi: 10.1186/s12875-023-02205-3.

MeSH Terms

Conditions

Smoking Cessation

Interventions

Therapeutics

Condition Hierarchy (Ancestors)

Health BehaviorBehavior

Central Study Contacts

Noelle E Natale

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
HEALTH SERVICES RESEARCH
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor

Study Record Dates

First Submitted

August 5, 2022

First Posted

August 9, 2022

Study Start

August 31, 2022

Primary Completion (Estimated)

December 31, 2026

Study Completion (Estimated)

December 31, 2026

Last Updated

March 5, 2026

Record last verified: 2026-03

Data Sharing

IPD Sharing
Will not share

Locations