Exercise With Audible Cues on Motor Unit Behavior in Athletes With Anterior Cruciate Ligament Reconstruction

NCT06662955 | Recruiting DMC

• 1 other identifier: MU-CIRB 2024/242.3009
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The closed kinetic chain (CKC) of terminal knee extension exercise (TKE) is designed to activate VM activity for knee injury training. This CKC exercise is effective for highest recruiting muscle activity, especially safe for post-operative knee surgery. The study of ACL reconstruction rehabilitation guideline suggests that exercises can be applied within the early phase of rehabilitation to prevent knee laxity and less knee pain compared to open chain exercise. Therefore, it is interesting to investigate the effects of TKE exercise synchronized with metronome pace on change of VM motor unit behavior in post operative ACL reconstruction. This study focuses on the immediate effect of 1-seesion TKE and expects that adding metronome during TKE will enhance neuromuscular control of VM and may change motor unit behavior.

Conditions

Physical Therapy Techniques; Therapeutic Exercise; Neuromuscular Function

Keywords

ACLR

Outcome Measures

Primary Outcomes (1)

• Average motor unit firing rate (pulse per second, pps)

  Motor unit behavior of vastus medialis muscle: Average motor unit firing rate (pulse per second, pps)

  From enrollment to the end of treatment at 2 weeks

Secondary Outcomes (1)

• Peak motor unit action potential (mV)

  From enrollment to the end of treatment at 2 weeks

Study Arms (2)

Exercise without audible cues

ACTIVE COMPARATOR

Terminal knee extension exercise without audible cues

Behavioral: Exercise

Exercise with audible cues

EXPERIMENTAL

Terminal knee extension exercise with audible cues

Behavioral: audible cues

Interventions

Exercise BEHAVIORAL

Terminal knee extension exercise

Exercise without audible cues

audible cues BEHAVIORAL

Terminal knee extension exercise with audible cues

Also known as: Exercise with audible cues

Exercise with audible cues

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Male or female participants who receive primary ACL reconstruction within 2 weeks with or without meniscus repair
• No or mild resting pain (Numeric rating scale ≤ 3)
• Reconstruction procedures using autograft including hamstrings or bone-patella bone grafts
• Age range 18-35 years (33).
• BMI of 18.5-25 kg/m² (34).
• Tegner activity scale ≥ level 4

You may not qualify if:

• Non-weight bearing within 2 weeks after the operation (prescription from surgeon)
• Hearing problem, such as being unable to hear the metronome sound or being unable to synchronize exercises with the metronome correctly
• Limitations in knee extension range caused by joint stiffness evaluated by using passive knee range of motion
• Unable to perform active and passive ≥ 30º knee flexion on the operative side
• History of serious injury or operation of lower back and lower extremities such as fracture
• Lower back or lower extremities pain within 6 months before the study
• On the pain killer medication

Sponsors & Collaborators

• Mahidol University: lead

Study Sites (1)

Faculty of Physical Therapy, Mahidol University

Salaya, Changwat Nakhon Pathom, 73170, Thailand

RECRUITING

MeSH Terms

Interventions

Exercise

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Central Study Contacts

Komsak Sinsurin, PT, Ph.D., DPT

CONTACT

6855547313; komsak.sin@mahidol.edu

Sakda Nitkotom, B.Sc.

CONTACT

0869853212; Sakda.nit@hotmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: Paticipants are blinded groups allocation.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Asst.Prof.Dr.

Study Record Dates

• First Submitted: October 25, 2024
• First Posted: October 29, 2024
• Study Start: October 20, 2024
• Primary Completion (Estimated): October 19, 2026
• Study Completion (Estimated): December 30, 2026
• Last Updated: December 12, 2025

Record last verified: 2025-12

Locations

TH (1)