The Immediate Effect of Combined Terminal Knee Extension Exercise With Audible Cues

NCT06565325 | Completed

• 1 other identifier: MU-CIRB 2024/021.0802
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Typically, patients perform TKE by themselves after exercise prescription. The investigators thought that a lack of attention and preferred speed of patients might not provide the best outcome. Therefore, an increased effectiveness of TKE is interesting for physical therapy implication. Besides, adding sensory input which is audible cues or rhythm during exercise may enhance the efficacy of the exercise by increasing neuromuscular control and function. Therefore, the study aimed to investigate the immediate effects of combined TKE with audible cues on motor unit behavior. The researchers expect that adding rhythm from the metronome will enhance neuromuscular control which may change motor unit behavior of VM muscle. The findings of the study may have helped explain the mechanism behind the acute effects of combined TKE with audible cues on VM function and their potential application in the field of physical therapy. This study aims to investigate the immediate effect of combined TKE with audible cues on motor unit behavior in healthy participants and to investigate reliability of decomposition electromyography procedure during single leg squat.

Conditions

Muscle Weakness

Keywords

Terminal Knee Extension Exercise; Audible Cues; Therapeutic exercise; Muscle strength

Outcome Measures

Primary Outcomes (2)

• Motor unit firing rate

  one parameter to explain the motor unit behavior of vastus medialis muscle

  At the end of Cycle 1 (each cycle is 1 day)

• Peak motor action potential

  one parameter to explain the motor unit behavior of vastus medialis muscle

  At the end of Cycle 1 (each cycle is 1 day)

Study Arms (2)

Experimental group

EXPERIMENTAL

Terminal Knee Extension Exercise with Audible Cues

Behavioral: Exercise + Audible Cues

Control group

ACTIVE COMPARATOR

Terminal Knee Extension Exercise without Audible Cues

Behavioral: Exercise

Interventions

Exercise + Audible Cues BEHAVIORAL

Combined Terminal Knee Extension Exercise with Audible Cues

Also known as: Metronome

Experimental group

Exercise BEHAVIORAL

Terminal Knee Extension Exercise

Control group

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Aged range between 18 and 30 years
• BMI of 18.5-25 kg/m2
• Male or female
• Lightly active or sedentary {Physical activity level (PAL= 1.4-1.69)}

You may not qualify if:

• History of serious injury or operation of lower back and lower extremities such as fracture
• Musculoskeletal problems of lower back and lower extremities in 6 months before the study
• Single-leg stance test \< 43 seconds (26). and range of weight-bearing lunge test \< 9.1 cm

Sponsors & Collaborators

• Mahidol University: lead

Study Sites (1)

Faculty of Physical Therapy, Mahidol University

Nakhon Pathom, Salaya, 73170, Thailand

Location

Related Publications (1)

• Suntornon P, Kiratisin P, Sinsurin K, Nitkotom S, Sonsukong A, Thong-On S, Watcharakeunkhan P, Sakunkaruna T. Exercise synchronized with audible cues preserves motor unit action potential: a randomized control trial study. BMC Sports Sci Med Rehabil. 2025 Dec 17. doi: 10.1186/s13102-025-01490-y. Online ahead of print.

  PMID: 41402906 DERIVED

MeSH Terms

Conditions

Muscle Weakness

Interventions

Exercise

Condition Hierarchy (Ancestors)

Muscular Diseases; Musculoskeletal Diseases; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: Participant group
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Asst.Prof.Dr.

Model Details: There are 2 groups in the current study including exercise with and without audible cues.

Study Record Dates

• First Submitted: August 11, 2024
• First Posted: August 21, 2024
• Study Start: February 10, 2024
• Primary Completion: February 7, 2025
• Study Completion: March 7, 2025
• Last Updated: July 29, 2025

Record last verified: 2025-07

Locations

TH (1)