Citizen Action for Sustainable Dengue Control in Sub-Saharan Africa

NCT06648603 | Completed

• 1 other identifier: C21047
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

This project focuses on addressing arboviral outbreaks in Ivory Coast by involving local communities in the sustainable control of Aedes mosquitoes, utilizing scientific advice and environmental interventions. It will evaluate the impact of a participatory strategy on decreasing mosquito populations and the risk of virus transmission, aiming to provide insights for policy development on disease prevention.

Conditions

Dengue

Keywords

Aedes Aegypti; Vector control; Community based intervention; Participatory research; Dengue; Africa; Ivory Coast

Outcome Measures

Primary Outcomes (1)

• Aedes aegypti mean number per trap per day

  Biting rate is the mean number of Aedes females per trap and per day. The proportion of unfed, fed, half-gravid and gravid females will be estimated.

  Continuously during months 1-4 (baseline) and months 5-17 (trial)

Secondary Outcomes (7)

• House index

  Before (month 1), twice during (month 4, 8) and once at the end of the trial (month 12)

• Pupal indices: pupae per person index, pupa index and pupae per hectare index

  Before (month 1), twice during (month 4, 8) and once at the end of the trial (month 12)

• Adults: parity rate

  Continuously during months 1-4 (baseline) and months 5-17 (trial)

• Knowledge, attitudes, and practices on Dengue prevention among the population of Cocody-Bingerville

  Before (month 1) the start of the trial and at the end of the trial (month 12)

• Mapping and describe Aedes aegypti breeding sites, focusing on their geographic and ecological characteristics. This mapping will be used to enhance targeted larval control efforts in these areas.

  Before (month 1) the start of the trial and at the end of the trial (month 12)

Study Arms (4)

Control

NO INTERVENTION

Non-intervened control arm: no community-based larval source management (LSM) or BG-GAT intervention

Community-based larval source management

EXPERIMENTAL

LSM intervention arm: Aedes larval source reduction carried out by trained and supervised local community members

Behavioral: Community-based larval source management

Enhanced Aedes adults trapping (BG-GAT)

EXPERIMENTAL

BG-GAT intervention arm: Aedes adult mass trapping by BG-GAT set up and maintained by trained and supervised local community members

Device: Enhanced Aedes adults trapping (BG-GAT)

Community-based larval source management + Enhanced Aedes adults trapping (BG-GAT)

EXPERIMENTAL

Combined LSM and BG-GAT intervention arm: simultaneous Aedes larval source reduction and Aedes adult mass trapping by BG-GAT carried out by trained and supervised local community members

Combination Product: Community-based larval source management with Enhanced Aedes adults trapping (BG-GAT)

Interventions

Community-based larval source management BEHAVIORAL

This project will foster active engagement with community stakeholders, including healthcare workers, community leaders, and other key informants, through participatory meetings aimed at co-creating and developing larval source reduction measures tailored to community's needs. This method emphasizes a participatory framework, ensuring that interventions are both community-informed and culturally relevant.

Community-based larval source management

Enhanced Aedes adults trapping (BG-GAT) DEVICE

Furthermore, the project intends to determine whether the addition of cost-effective, gravid female mosquito-targeting traps, specifically two Biogents Gravid Aedes Traps (BG-GAT) per household, can improve the overall success of these community-based intervention.

Enhanced Aedes adults trapping (BG-GAT)

Community-based larval source management with Enhanced Aedes adults trapping (BG-GAT) COMBINATION_PRODUCT

The community-based interventions and the BG-GAT deployment will be evaluated in combination to assess their individual and synergistic effects on vector control. This dual strategy combines local participation and practical, evidence-based solutions to address mosquito-borne illness transmission.

Community-based larval source management + Enhanced Aedes adults trapping (BG-GAT)

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Geographical location: households must be located within the designated clusters in the two districts involved in the trial.
• Participation in cluster arms: households must belong to a cluster that is assigned to one of the four arms (1. Control, 2. Community-based larval source management, 3 Enhanced Aedes adults trapping (BG-GAT), 4. Enhanced Aedes adults trapping (BG-GAT) + Community-based larval source management).
• Willingness to participate: households agreed to allow researchers to place mosquito traps and conduct larval and adult mosquito surveys.
• Socio-Environmental Data: households must agree and provide consent to participate to the socio-environmental questionnaire.

You may not qualify if:

• Outside of trial clusters: households located outside the designated clusters in the two districts were excluded.
• Refusal to participate: households that do not consent to mosquito trap placement or surveys
• Inaccessibility: households that are not accessible for regular visits or data collection (e.g., due to relocation or difficult terrain).

Sponsors & Collaborators

• Swiss Tropical & Public Health Institute: lead
• Centre Suisse de Recherches Scientifiques en Cote d'Ivoire: collaborator

Study Sites (1)

Centre Suisse de Recherches Scientifiques en Côte d'Ivoire

Abidjan, Côte d’Ivoire

Location

MeSH Terms

Conditions

Dengue

Condition Hierarchy (Ancestors)

Mosquito-Borne Diseases; Vector Borne Diseases; Infections; Arbovirus Infections; Virus Diseases; Flavivirus Infections; Flaviviridae Infections; RNA Virus Infections; Hemorrhagic Fevers, Viral

Study Officials

• Pie Müller, PD, PhD

  Swiss Tropical & Public Health Institute

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: Statistician unaware of the arms allocation
• Purpose: PREVENTION
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Cluster randomized trial with 2x2 factorial design - 40 clusters, 10 clusters per study arm (4 arms)

Study Record Dates

• First Submitted: July 1, 2024
• First Posted: October 18, 2024
• Study Start: July 15, 2023
• Primary Completion: July 31, 2024
• Study Completion: September 30, 2024
• Last Updated: October 22, 2024

Record last verified: 2023-12

Data Sharing

• IPD Sharing: Will not share

Locations

CÔ (1)