Feasibility of Deep Inspiratory Internal Jugular Vein Variability in Guiding Preoperative Fluid Replacement
1 other identifier
interventional
80
1 country
1
Brief Summary
Compare the incidence of hypotension during the propofol-induced period between the internal jugular vein variability-guided fluid infusion group and the conventional fluid infusion group through a fluid infusion experiment before anesthesia induction, so as to evaluate the feasibility of using the internal jugular vein variability under deep inspiration to guide preoperative fluid infusion.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Aug 2024
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2024
CompletedFirst Submitted
Initial submission to the registry
October 12, 2024
CompletedFirst Posted
Study publicly available on registry
October 15, 2024
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2025
CompletedNovember 15, 2024
August 1, 2024
10 months
October 12, 2024
November 13, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
The incidence of a 20% drop in blood pressure after propofol induction
The incidence of a 20% drop in blood pressure after propofol induction
1 year
Study Arms (2)
Guiding rehydration group
EXPERIMENTALAccording to the 421 fluid replacement principle, preoperative fluid replacement is performed
Conventional rehydration group
ACTIVE COMPARATORrehydrated within 15 minutes according to 0.2ml/kg/min.
Interventions
Preoperative fluid rehydration was performed according to 421 fluid rehydration principles
Eligibility Criteria
You may qualify if:
- age over 60 years； American Society of Anesthesiology (ASA) status Ⅱ-Ⅲ； Surgery with radial artery puncture； Propofol induction；
You may not qualify if:
- BMI≥30kg/m2； People with short necks； Previous hypotension (systolic blood pressure \<90mmHg or mean arterial pressure\<65mmHg)； Previous poorly controlled hypertension； Cardiac insufficiency , EF value\<50%； Upper limb deep vein thrombosis； History of radiotherapy or neck surgery； Inability to maintain a supine position for necessary measurements； Mechanical ventilation status or inability to take deep breaths patients； gastrointestinal surgery； Patients allergic to propofol； Restricted fluid intake；
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Affiliated Hospital of University
Jiaxing, Zhejiang, China
Related Publications (1)
Wei XL, Xi YZ, Xie L, Li ZP, Tang HL, Zhou QH. Effects of liquid resuscitation guided by internal jugular vein variability during deep inhalation on preventing propofol-induced hypotension in elderly patients. BMC Anesthesiol. 2025 Jul 17;25(1):350. doi: 10.1186/s12871-025-03227-3.
PMID: 40676549DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Qinghe Zhou
Affiliated Hospital of Jiaxing University
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Masking Details
- single
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal investigator
Study Record Dates
First Submitted
October 12, 2024
First Posted
October 15, 2024
Study Start
August 1, 2024
Primary Completion
June 1, 2025
Study Completion
June 1, 2025
Last Updated
November 15, 2024
Record last verified: 2024-08
Data Sharing
- IPD Sharing
- Will not share