NCT06112769

Brief Summary

The correlation between internal jugular vein variability during deep inhalation and the decrease in blood pressure during propofol induction.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
64

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Oct 2023

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

October 29, 2023

Completed
Same day until next milestone

Study Start

First participant enrolled

October 29, 2023

Completed
3 days until next milestone

First Posted

Study publicly available on registry

November 1, 2023

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 31, 2024

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 31, 2024

Completed
Last Updated

March 12, 2025

Status Verified

March 1, 2025

Enrollment Period

3 months

First QC Date

October 29, 2023

Last Update Submit

March 10, 2025

Conditions

Hemodynamic

Keywords

Internal jugular veinpropofolhypotensionhemodynamic

Outcome Measures

Primary Outcomes (1)

  • IJVV during deep inhalation

    IJVV (%) = (diamax - diamin)/\[(diamax + diamin)/2\] × 100

    1 year

Eligibility Criteria

Age60 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Patients undergoing intravenous general anesthesia surgery at Jiaxing First Hospital

You may qualify if:

  • age over 60 years
  • American Society of Anesthesiology (ASA) status Ⅱ-Ⅲ
  • Surgery with radial artery puncture
  • Propofol induction

You may not qualify if:

  • BMI≥30kg/m2
  • People with short necks;
  • Previous hypotension (systolic blood pressure \<90mmHg or mean arterial pressure \<65mmHg)
  • Previous poorly controlled hypertension
  • Cardiac insufficiency , EF value\<50%
  • Upper limb deep vein thrombosis
  • History of radiotherapy or neck surgery
  • Inability to maintain a supine position for necessary measurements
  • Mechanical ventilation status or inability to take deep breaths patients
  • gastrointestinal surgery
  • patients allergic to propofol.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Affiliated Hospital of Jiaxing University

Jiaxing, Zhejiang, 314000, China

Location

Related Publications (1)

  • Wei XL, Xi YZ, Xie L, Li ZP, Tang HL, Zhou QH. Effects of liquid resuscitation guided by internal jugular vein variability during deep inhalation on preventing propofol-induced hypotension in elderly patients. BMC Anesthesiol. 2025 Jul 17;25(1):350. doi: 10.1186/s12871-025-03227-3.

    PMID: 40676549DERIVED

MeSH Terms

Conditions

Hypotension

Condition Hierarchy (Ancestors)

Vascular DiseasesCardiovascular Diseases

Study Officials

  • Qinghe Zhou

    Affiliated Hospital of Jiaxing University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
PROSPECTIVE
Target Duration
1 Day
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal investigator

Study Record Dates

First Submitted

October 29, 2023

First Posted

November 1, 2023

Study Start

October 29, 2023

Primary Completion

January 31, 2024

Study Completion

January 31, 2024

Last Updated

March 12, 2025

Record last verified: 2025-03

Data Sharing

IPD Sharing
Will not share

Locations

CN(1)