Oral and Dental Health in Substance Dependent Individuals

NCT06640712 | Completed

• 1 other identifier: 2024/234
• Study Type: interventional
• Target: 281
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this cross-sectional clinical study is to compare the oral health status of individuals with Methamphetamine (MA), Cannabis (THC), and Polysubstance (PSU) use disorders to healthy controls. The study aims to answer: How does substance use type (Methamphetamine, Cannabis, Polysubstance) affect dental health outcomes as measured by the DMFT index? What is the relationship between substance use characteristics (type, duration, and quantity) and oral health behaviors? Researchers will compare individuals with substance use disorders to a control group of healthy, non-substance-using individuals to assess the impact of different substances on dental health. Participants will: Undergo a clinical oral examination to evaluate dental health using the DMFT index. Complete a questionnaire on sociodemographic information, substance use history, and oral health behaviors based on the Hiroshima University Dental Behavior Inventory (HU-DBI). This study contributes to understanding the dental health needs of individuals with substance use disorders and the importance of tailored dental interventions for this population.

Conditions

Substance Use Disorder (SUD); Decayed Teeth; Teeth Loss; Teeth Missing

Keywords

substance use disorder; Oral health; DMTF index; Oral health behaviors

Outcome Measures

Primary Outcomes (1)

• Compare the oral health status of individuals with Methamphetamine (MA), Cannabis (THC), and Polysubstance (PSU) Use Disorders to healthy controls assessed by DMFT index

  Dental caries was assessed using the DMFT index (Decayed, Missing, and Filled Teeth) according to the World Health Organization's caries diagnostic criteria. This index included the number of decayed, missing (due to caries, excluding 3rd molars), and filled teeth in the permanent dentition. A minimum score of 0 and a maximum score of 28 can be obtained on the DMFT scale, with higher scores indicating poorer oral health.

  Up to 24 weeks

Study Arms (4)

Arm 1: Methamphetamine Use Group

EXPERIMENTAL

This group consists of individuals diagnosed with Methamphetamine Use Disorder. Diagnoses were conducted by the same psychiatrist for all participants. Following psychiatric evaluation, participants underwent a clinical oral health examination to assess their dental health status, with the Decayed, Missing, and Filled Teeth (DMFT) index being calculated afterward. This group is included to investigate the impact of methamphetamine use on oral health.

Diagnostic Test: Dental caries was assessed using the DMFT index (Decayed, Missing, and Filled Teeth) according to the World Health Organization's caries diagnostic criteria.; Diagnostic Test: Substance Use Disorder Diagnosis

Arm 2: Cannabis Use Group

EXPERIMENTAL

This group consists of individuals diagnosed with Cannabis Use Disorder. Diagnoses were performed by the same psychiatrist for consistency. After the psychiatric assessment, participants received a clinical oral health examination to determine their dental health status, and the DMFT index was calculated subsequently. This group aims to assess the effects of cannabis use on oral health.

Diagnostic Test: Dental caries was assessed using the DMFT index (Decayed, Missing, and Filled Teeth) according to the World Health Organization's caries diagnostic criteria.; Diagnostic Test: Substance Use Disorder Diagnosis

Arm 3: Polysubstance Use Group

EXPERIMENTAL

This group includes individuals who use multiple substances (polysubstance use disorder). All participants were evaluated by the same psychiatrist to ensure diagnostic accuracy. Following their psychiatric evaluation, participants had a clinical oral health examination, during which the DMFT index was calculated to assess dental health. This group is included to examine the impact of polysubstance use on oral health.

Diagnostic Test: Dental caries was assessed using the DMFT index (Decayed, Missing, and Filled Teeth) according to the World Health Organization's caries diagnostic criteria.; Diagnostic Test: Substance Use Disorder Diagnosis

Arm 4: Control Group

OTHER

Healthy, non-substance-using individuals This group consists of healthy individuals with no history of substance use, systemic medical conditions, or regular medication use. Diagnoses were confirmed by the same psychiatrist. Afterward, participants underwent a clinical oral health examination, and the DMFT index was calculated to provide a baseline for comparison with substance-using groups. This group serves as the control group to compare the dental health outcomes of non-substance-using individuals.

Diagnostic Test: Dental caries was assessed using the DMFT index (Decayed, Missing, and Filled Teeth) according to the World Health Organization's caries diagnostic criteria.

Interventions

Dental caries was assessed using the DMFT index (Decayed, Missing, and Filled Teeth) according to the World Health Organization's caries diagnostic criteria. DIAGNOSTIC_TEST

The same psychiatrist administered the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) to all participants. Oral health examinations were performed by a trained dental student and a specialist dentist using a portable dental chair, artificial light, and a dental mirror. Dental caries was assessed using the DMFT index (Decayed, Missing, and Filled Teeth) according to the World Health Organization's caries diagnostic criteria. This index included the number of decayed, missing (due to caries, excluding 3rd molars), and filled teeth in the permanent dentition. The oral health examiners were blinded to each participant's substance use type and sociodemographic information.

Arm 1: Methamphetamine Use Group; Arm 2: Cannabis Use Group; Arm 3: Polysubstance Use Group; Arm 4: Control Group

Substance Use Disorder Diagnosis DIAGNOSTIC_TEST

This intervention involves a psychiatric evaluation conducted by a licensed psychiatrist to diagnose Substance Use Disorder according to the criteria outlined in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). The psychiatrist performs a comprehensive assessment of each participant's substance use history and related behaviors. This diagnosis step is essential for identifying participants with specific substance use disorders, such as Methamphetamine, Cannabis, or Polysubstance Use Disorders, before proceeding with the dental health examination.

Arm 1: Methamphetamine Use Group; Arm 2: Cannabis Use Group; Arm 3: Polysubstance Use Group

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Male participants
• aged 18 to 45
• methamphetamine, cannabis, or polysubstance users.

You may not qualify if:

• absence of urine toxicology analysis results,
• use of substances other than methamphetamine or cannabis,
• being under the influence of substances during the evaluation
• not meeting DSM-5 criteria for Substance Use Disorder,
• having any systemic medical conditions
• current medication use
• incomplete scales and forms.
• who wore removable dentures
• In the control group, individuals with a history of any substance use

Sponsors & Collaborators

• Izmir Democracy University: lead

Study Sites (1)

İzmir Demokrasi Üniversitesi

Izmir, Konak, Turkey (Türkiye)

Location

Related Publications (1)

• Kilic OHT, Kurklu Arpacay D, Gezen OC, Bayram ZN, Baser A. Comparative effects of methamphetamine, cannabis, and polysubstance use on oral health. Front Psychiatry. 2025 Jan 31;16:1510228. doi: 10.3389/fpsyt.2025.1510228. eCollection 2025.

  PMID: 39958156 DERIVED

Related Links

• The study was conducted at the İzmir Democracy University Buca Seyfi Demirsoy Education and Research Hospital's Probation Clinic (Denetimli Serbestlik Polikliniği). This clinic provides treatment and evaluation services for individuals who have been man

MeSH Terms

Conditions

Substance-Related Disorders; Dental Caries; Anodontia

Interventions

Metabolism

Condition Hierarchy (Ancestors)

Chemically-Induced Disorders; Mental Disorders; Tooth Demineralization; Tooth Diseases; Stomatognathic Diseases; Tooth Abnormalities; Stomatognathic System Abnormalities; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Study Officials

• Osman HT Kılıç, Asist. Prof.

  Izmir Democracy University

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Asistant Profesor

Model Details: his study uses a parallel design to compare the oral health status among individuals with different substance use disorders (Methamphetamine, Cannabis, Polysubstance) and a healthy control group.

Study Record Dates

• First Submitted: October 9, 2024
• First Posted: October 15, 2024
• Study Start: April 25, 2024
• Primary Completion: August 25, 2024
• Study Completion: August 25, 2024
• Last Updated: October 15, 2024

Record last verified: 2024-10

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, CSR, ANALYTIC CODE
• Time Frame: The IPD and supporting information will be available after the study has been published in an international peer-reviewed journal and will remain accessible for five years following publication.
• Access Criteria: ccess will be granted to qualified researchers who provide a scientific rationale for data usage and agree to sign a data use agreement. This agreement will stipulate that the data will be used exclusively for scientific research purposes

Locations

TU (1)