Large-scale Multi-omics Analysis of Cerebrospinal Fluid
Deputy Director of Department of Neurosurgery, the Second Affiliated Hospital of Zhejiang University School of Medicine；Professor；
1 other identifier
observational
150
1 country
1
Brief Summary
The aim of this study is to explore the role of cerebrospinal fluid (CSF) biomarkers in aging and neurodegenerative diseases.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Mar 2024
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2024
CompletedFirst Submitted
Initial submission to the registry
August 25, 2024
CompletedFirst Posted
Study publicly available on registry
October 10, 2024
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2025
CompletedOctober 10, 2024
August 1, 2024
1 year
August 25, 2024
October 8, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Cerebrospinal fluid (CSF) biomarkers
CSF samples from different ages were analyzed to identify biomarkers that change significantly during aging, such as amyloid beta (Aβ42), Tau protein (including the phosphorylated form p-tau181), and other proteins associated with neuroinflammation and blood-brain barrier function
December 2024
Eligibility Criteria
Patients admitted for spinal anesthesia surgery due to non-neurological conditions and pediatric patients undergoing surgery for tethered spinal cord syndrome.
You may qualify if:
- Patients aged 0 to 90 years will be selected for the study.
- Patients admitted for surgery under spinal anesthesia due to non-neurological conditions, such as lower limb fractures or hemorrhoids.
- Pediatric patients undergoing surgical treatment for tethered spinal cord syndrome.
You may not qualify if:
- Patients with neurological conditions, including encephalitis, Parkinson's disease, Alzheimer's disease, hydrocephalus, brain tumors, and psychiatric disorders.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
The Second Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, Zhejiang, 310058, China
Biospecimen
cerebrospinal fluid
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
August 25, 2024
First Posted
October 10, 2024
Study Start
March 1, 2024
Primary Completion
March 1, 2025
Study Completion
April 1, 2025
Last Updated
October 10, 2024
Record last verified: 2024-08