NCT05256251

Brief Summary

The Westlake Longevity Cohort (We-Longevity) is a prospective cohort study among centenarians, nonagenarians and senior citizens living in Lishui, China. The primary aim of this cohort is to characterize the multi-omics molecular characteristics of healthy longevity and their dynamic trajectories. The second aim is to culture the gut microbiota of these elderly people through culturomics. The third aim of We-Longevity is to investigate the association of dietary and lifestyle with the multi-omics molecular characteristics of healthy longevity, and to facilitate the development of personalized nutritional/lifestyle recommendation for the public.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,500

participants targeted

Target at P75+ for all trials

Timeline
68mo left

Started Nov 2021

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress45%
Nov 2021Nov 2031

First Submitted

Initial submission to the registry

November 15, 2021

Completed
Same day until next milestone

Study Start

First participant enrolled

November 15, 2021

Completed
3 months until next milestone

First Posted

Study publicly available on registry

February 25, 2022

Completed
3.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 14, 2025

Completed
6 years until next milestone

Study Completion

Last participant's last visit for all outcomes

November 14, 2031

Expected
Last Updated

June 15, 2025

Status Verified

March 1, 2025

Enrollment Period

4 years

First QC Date

November 15, 2021

Last Update Submit

June 10, 2025

Conditions

Aging

Keywords

Gut microbiomeAging

Outcome Measures

Primary Outcomes (2)

  • Physical frailty

    Physical frailty will be evaluated by using Fried's criteria.

    36 months

  • Gut microbiome

    Fecal microbiome will be analyzed by 16S/ITS rRNA gene sequencing and metagenome sequencing. Furthermore, fecal microbiota will be cultured, picked and identified.

    36 months

Secondary Outcomes (3)

  • Cognitive function

    36 months

  • Blood biochemical parameters

    36 months

  • Metabolomics profiling

    36 months

Eligibility Criteria

Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

All the participants should be Chinese residents, regardless of the ethics.

You may qualify if:

  • Participants live in Lishui, China.
  • Participants intend to remain in Lishui for ≥3 years.

You may not qualify if:

  • Participants with infectious diseases.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Lishui Yikang Hospital

Lishui, Zhejiang, 323000, China

RECRUITING

Study Officials

  • Ju-Sheng Zheng, PhD

    Westlake University

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Ju-Sheng Zheng, PhD

CONTACT

86-0571-86915303zhengjusheng@westlake.edu.cn

Junhui Zhang, PhD

CONTACT

86-0571-86915303zhangjunhui@westlake.edu.cn

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
3 Years
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 15, 2021

First Posted

February 25, 2022

Study Start

November 15, 2021

Primary Completion

November 14, 2025

Study Completion (Estimated)

November 14, 2031

Last Updated

June 15, 2025

Record last verified: 2025-03

Locations

CN(1)