Targeting Aging and Promoting Longevity with Exogenous Nucleotides (TALENTs)

NCT05243108 | Completed

• 1 other identifier: TALENTs
• Study Type: interventional
• Target: 122
• Locations: 1 country
• Sites: 1

Brief Summary

To investigate the effects of dietary nucleotides (NTs) as an anti-aging supplement, a clinical trial is carried as a randomized, double-blind, parallel design, placebo-controlled. A total of 120 subjects will be enrolled in the study, and they shall be randomly distributed between the two arms, NTs-treated, and placebo-control. They would be given several measurements, including physical examination, questionnaire survey, clinical and aging-related biomarkers tests at 0 (baseline), 2, and 4 months during the RCT.

Conditions

Aging

Keywords

anti-aging; DNA methylation age; Insulin Sensitivity/Resistance

Outcome Measures

Primary Outcomes (2)

• DNAmAge

  DNA methylation clocks were assessed through whole-genome bisulfite sequencing (WGBS).The median of four principal component (PC)-corrected clocks (Horvath, Hannum, GrimAge, and PhenoAge) was chosen as the DNA methylation age outcome measure.

  Baseline、At 2 months、At 4 months

• The length of Leukocyte telomere

  Telomere length was quantified via quantitative PCR, using telomeric DNA amplification compared to a reference gene.

  Baseline、At 2 months、At 4 months

Secondary Outcomes (23)

• glycolipid metabolic profile

  Baseline、 At 2 months、 At 4 months

• Body composition

  Baseline、At 2 months、At 4 months

• Phenotypic Age

  Baseline、 At 2 months、 At 4 months

• Spontaneous fluorescence of subcutaneous AGEs

  Baseline、At 4 months

• Carotid thickness of intima media

  Baseline、At 2 months、At 4 months

Other Outcomes (3)

• Gut microbiota

  Baseline、At 4 months

• Scores of Quality of life

  Baseline、At 4 months

• Dietary intake

  Baseline、 At 4 months

Study Arms (2)

NTs Intervention group

EXPERIMENTAL

The subject of 1200mg has been given orally once a day for 4 months.

Dietary Supplement: dietary nucleotides

placebo control group

PLACEBO COMPARATOR

The ingredients, dosage, and usage are the same as experimental.

Dietary Supplement: placebo

Interventions

dietary nucleotides DIETARY_SUPPLEMENT

1.2 g/d NTs (5 '-AMP, 5' -CMP, 5 '-GMPNa2, 5' -UMPNa2) ;

NTs Intervention group

placebo DIETARY_SUPPLEMENT

placebo

placebo control group

Eligibility Criteria

• Age: 60 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Male/females of 60 to 70 years of age
• No serious physical or mental illness
• Able to provide written Informed Consent
• Able to follow verbal and written study directions
• Must not be taking or be willing to take any supplements containing any form of nucleotides for one year prior to baseline and for the duration of the study.
• Able to maintain consistent diet and lifestyle habits throughout the study
• Willing to consume assigned supplement (NTs or placebo) for 4 months

You may not qualify if:

• Participants on the current use of prescription or over-the-counter nucleotides
• Having abnormal screening laboratory test values or other lab test result(s) that would preclude study participation in the judgment of the investigator
• Documented presence of atherosclerotic disease and/or cardiopulmonary disease
• History of drug or alcohol abuse
• History of unstable depression or mental illness within the last 6 months for which the investigator believes could impact the participant's ability to comply with study requirements
• Other diseases or medications, according to the investigator, that would interfere directly in the results of the study or jeopardize the health of the participant.
• Currently, or within the past 30 days, enrolled in a different clinical investigation
• Inability to provide a venous blood sample
• Unable or unwilling to provide written informed consent for participation in the study

Sponsors & Collaborators

• Peking University: lead

Study Sites (1)

Talents project team

Chengdu, Sichuan, 610095, China

Location

Related Publications (1)

• Wang S, Song L, Fan R, Chen Q, Fu R, You M, Wu Y, Cai M, Li Y, Xu M. Nucleotides as an Anti-Aging Supplementation in Older Adults: A Randomized Controlled Trial (TALENTs study). Adv Sci (Weinh). 2025 Sep;12(33):e2417728. doi: 10.1002/advs.202417728. Epub 2025 May 28.

  PMID: 40433895 DERIVED

MeSH Terms

Conditions

Insulin Resistance

Condition Hierarchy (Ancestors)

Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Officials

• Meihong Xu, Assis prof.

  Peking University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: The experiment designers used seed number 1234 to generate a random sequence of 120 random numbers on SAS software and divided the 120 random numbers into two groups based on the size of the random numbers. The larger number is Group A, and the smaller number is Group B. Both intervention drugs and placebos are produced by pharmaceutical companies without any labels and look exactly the same. Neither the trial designer nor the pharmacist participated in the trial. The researchers were responsible for recruiting subjects and assigning serial numbers according to inclusion criteria. Caregivers are responsible for dispensing, reviewing, and documenting medications. Investigators are responsible for measuring and filling out questionnaire items. Medical examinations and sample collection are carried out by hospital professionals.
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate professor

Model Details: completely randomized design

Study Record Dates

• First Submitted: November 26, 2021
• First Posted: February 16, 2022
• Study Start: August 23, 2022
• Primary Completion: March 29, 2023
• Study Completion: March 29, 2023
• Last Updated: January 29, 2025

Record last verified: 2025-01

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)