Systemic Inflammatory Biomarkers in Ovarian Cancer

NCT06629831 | Completed

• 1 other identifier: 2024-59
• Study Type: observational
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

In cancer patients, prognostic markers are needed to improve the management and clinical course of both the cancer itself and surgery therefor. Elevated systemic inflammatory markers are associated with morbidity and mortality in most cancer types. In this study, the investigators aimed to determine the prognostic value of inflammatory markers such as neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and lymphocyte to monocyte ratio (LMR) in patients undergoing cytoreductive surgery for ovarian cancer.

Conditions

Ovarian Cancer

Keywords

systemic inflammatory markers; ovarian cancer; cytoreductive surgery

Outcome Measures

Primary Outcomes (1)

• the rate of systemic inflammatory biomarkers

  the investigator planned to evaluate the prognostic effect of systemic inflammatory biomarkers on postoperative complications.

  up to 24 hours postoperative

Study Arms (1)

Patients undergoing cytoreduction surgery for ovarian cancer

Patients undergoing cytoreduction surgery for ovarian cancer

Other: group with complications; Other: group without complications

Interventions

group with complications OTHER

Complications in patients undergoing cytoreduction surgery for ovarian cancer

Patients undergoing cytoreduction surgery for ovarian cancer

group without complications OTHER

Complications in patients undergoing cytoreduction surgery for ovarian cancer

Patients undergoing cytoreduction surgery for ovarian cancer

Eligibility Criteria

• Age: 18 Years+
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

A total of 187 patients who were operated in the gynecologic surgical oncology clinic in one year were retrospectively evaluated.

You may qualify if:

• Patients older than 18 years of age

You may not qualify if:

• Patients with acute or inflammatory diseases
• Patients with hematological malignancies
• Patients with autoimmune diseases patients who underwent intraoperative hyperchemotherapy (HIPEC)

Sponsors & Collaborators

• Bakirkoy Dr. Sadi Konuk Research and Training Hospital: lead

Study Sites (1)

BasaksehiCam and Sakura City Hospital

Istanbul, Istanbul, Turkey (Türkiye)

Location

Related Publications (4)

• He W, Yin C, Guo G, Jiang C, Wang F, Qiu H, Chen X, Rong R, Zhang B, Xia L. Initial neutrophil lymphocyte ratio is superior to platelet lymphocyte ratio as an adverse prognostic and predictive factor in metastatic colorectal cancer. Med Oncol. 2013 Mar;30(1):439. doi: 10.1007/s12032-012-0439-x. Epub 2013 Jan 10.

  PMID: 23307251 BACKGROUND

• Oreskov KO, Jensen KK, Gogenur I, Godthaab C, Jorgensen AB, Oreskov JO, Burcharth J, Ekeloef S. Limited value of preoperative neutrophil-to-lymphocyte ratio to predict post-operative outcomes after major emergency abdominal surgery. Dan Med J. 2021 Aug 20;68(9):A09200689.

  PMID: 34477095 BACKGROUND

• Forget P, Dinant V, De Kock M. Is the Neutrophil-to-Lymphocyte Ratio more correlated than C-reactive protein with postoperative complications after major abdominal surgery? PeerJ. 2015 Jan 13;3:e713. doi: 10.7717/peerj.713. eCollection 2015.

  PMID: 25653901 BACKGROUND

• Lapchak PH, Kannan L, Ioannou A, Rani P, Karian P, Dalle Lucca JJ, Tsokos GC. Platelets orchestrate remote tissue damage after mesenteric ischemia-reperfusion. Am J Physiol Gastrointest Liver Physiol. 2012 Apr 15;302(8):G888-97. doi: 10.1152/ajpgi.00499.2011. Epub 2012 Feb 2.

  PMID: 22301111 BACKGROUND

MeSH Terms

Conditions

Ovarian Neoplasms

Interventions

Population Groups

Condition Hierarchy (Ancestors)

Endocrine Gland Neoplasms; Neoplasms by Site; Neoplasms; Ovarian Diseases; Adnexal Diseases; Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Neoplasms, Female; Urogenital Neoplasms; Genital Diseases; Endocrine System Diseases; Gonadal Disorders

Intervention Hierarchy (Ancestors)

Demography; Population Characteristics

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: September 27, 2024
• First Posted: October 8, 2024
• Study Start: December 1, 2022
• Primary Completion: December 1, 2023
• Study Completion: September 27, 2024
• Last Updated: October 9, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)