Thiol-disulfide Homeostasis in Patients With Ovarian Cancer

NCT05011539 | Completed

• 1 other identifier: TepecikTRH-AKarabulut-001
• Study Type: observational
• Target: 115
• Locations: 1 country
• Sites: 1

Brief Summary

Ovarian cancer is the third most common after endometrial and cervical cancer in societies with a high standard of living; It is the second most common type of gynecological cancer after cervical cancer in societies with a low standard of living, and it is also the deadliest among gynecological cancers. Dynamic thiol-disulfide homeostasis is an antioxidant system that minimizes oxidative damage and prevents cell damage. In the presence of oxidative stress, the thiol groups combine to form the disulfide structure, and when the oxidative stress condition is over, they are separated into thiol groups again. This homeostasis is impaired in conditions that cause oxidative processes such as diabetes, cardiovascular diseases, cancers, rheumatoid arthritis, and chronic kidney failure. This can be determined by measuring the total thiol and native thiol levels. Likewise, the level of ischemia modified albumin increases in the case of oxidative stress. There are studies on this homeostasis in the literature on many types of cancer; There are studies on endometrial cancer and cervical cancer, which are gynecological cancers In this study, the usability of these tests together with other diagnostic tests in the diagnosis of ovarian cancer will be evaluated.

Conditions

Ovarian Cancer

Outcome Measures

Primary Outcomes (1)

• thiol - disulfide levels

  the rate of total thiol, native thiol and total oxidant/antioxidant capacity

  April 2021 - January 2022

Study Arms (2)

Ovarian cancer

The patients with ovarian cancer

Control group

Eligibility Criteria

• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Ovarian cancer patients who applied to Izmir Tepecik Training and Research Hospital

You may qualify if:

• Histopathological diagnosis of ovarian cancer

You may not qualify if:

• Having an acute or chronic disease that will cause oxidative stress
• Using alcohol/cigarettes/drugs
• Using antioxidant agents (such as vitamins A, C, E)

Sponsors & Collaborators

• Tepecik Training and Research Hospital: lead

Study Sites (1)

Izmir Tepecik Training and Research Hospital

Izmir, Konak, 35020, Turkey (Türkiye)

Location

Related Publications (1)

• Sezgin B, Kinci MF, Pirincci F, Camuzcuoglu A, Erel O, Neselioglu S, Camuzcuoglu H. Thiol-disulfide status of patients with cervical cancer. J Obstet Gynaecol Res. 2020 Nov;46(11):2423-2429. doi: 10.1111/jog.14480. Epub 2020 Sep 9.

  PMID: 32909381 BACKGROUND

Biospecimen

Retention: SAMPLES WITH DNA

blood samples

MeSH Terms

Conditions

Ovarian Neoplasms

Condition Hierarchy (Ancestors)

Endocrine Gland Neoplasms; Neoplasms by Site; Neoplasms; Ovarian Diseases; Adnexal Diseases; Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Neoplasms, Female; Urogenital Neoplasms; Genital Diseases; Endocrine System Diseases; Gonadal Disorders

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Medical Doctor

Study Record Dates

• First Submitted: August 15, 2021
• First Posted: August 18, 2021
• Study Start: April 9, 2021
• Primary Completion: April 1, 2022
• Study Completion: May 1, 2022
• Last Updated: October 20, 2022

Record last verified: 2022-10

Locations

TU (1)