Perceptual-vision Training and Intellectual Disabilities

NCT06628999 | Withdrawn

• 1 other identifier: 0119168
• Study Type: interventional
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

Physical activity for healthy ageing is an important feature and the possibility to detect practical solutions to solve the need for feasible health promotion interventions to reduce health disparities and wellbeing in individuals with intellectual disability (ID) is an open question. In this perspective, vision has a remarkable role in spatial cognition and organization, especially in individuals with ID. Therefore, the aim is to investigate the effectiveness of a perceptual-vision training program on cognitive performance (inhibitory control) and physical fitness (balance, agility and muscular strength) in adults with ID throughout 16 weeks. Participants with mild ID will be randomly divided into a perceptual-vision training group, a perceptual-vision training-detraining group and a control group. Cognitive performance and physical fitness will be assessed at baseline, mid and at the end of 16 weeks. In conclusion, a visual training program may present the potentiality to impact various health domains, from cognition to physical performance in individuals with intellectual disabilities, promoting their healthy aging.

Conditions

Intellectual Disability; Intellectual Impairment; Activity, Motor; Sports Physical Therapy

Keywords

Visual training; Intellectual disability; Physical activity

Outcome Measures

Primary Outcomes (1)

• Change from baseline cognitive performance at 16 week

  Response time on a computerized test conceptualized as a measure of cognitive performance inhibitory control (Modified Flanker Task test). Participants are tasked with identifying the direction of the central target stimulus that is flanked by either congruent (\<\<\<\<\<) or incongruent (\>\>\<\>\>) stimuli by pressing the correct keyboard key.

  Up to sixteen weeks

Secondary Outcomes (4)

• Change from baseline static balance at 16 week

  Up to sixteen weeks

• Change from baseline strength at 16 week

  Up to sixteen weeks

• Change from baseline strength at 16 week

  Up to sixteen weeks

• Change from baseline movement agility at 16 week

  Up to sixteen weeks

Study Arms (3)

Visual Training Group

EXPERIMENTAL

Visual Training Group: physical training exercises aiming to combine visual skills with basic motor actions for 16 consecutive weeks

Other: Visual Training

Control Group

ACTIVE COMPARATOR

Control Group: active lifestyle based on healthy habits for 16 consecutive weeks

Other: Control Group

Visual Training-detraining Group

EXPERIMENTAL

Visual Training-detraining Group: physical exercises physical training exercises aiming to combine visual skills with basic motor actions for 8 consecutive weeks. The last remaining 8 weeks (up to 16 week) the group will conduct a period of detraining in which no physical exercises will be administered

Other: Visual Training-detraining

Interventions

Visual Training OTHER

16-week training protocol focused on visual training designed for ameliorating cognitive performance and physical fitness

Visual Training Group

Control Group OTHER

16-week of active lifestyle based on healthy habits

Control Group

Visual Training-detraining OTHER

8-week training protocol focused on visual training designed for ameliorating cognitive performance and physical fitness, followed by 8 week with no specific training protocol

Visual Training-detraining Group

Eligibility Criteria

• Age: 40 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• age between 40 and 70 years
• mild ID (Intellectual Quotient = 51-69).

You may not qualify if:

• inability to understand basic verbal communication
• strict dependence on personnel or assistive support devices
• presence of concomitant sensorial or physical impairments
• presence of behavioural problems or any other clinical condition that may compromise the regular physical activity practice

Sponsors & Collaborators

• Università degli Studi dell'Insubria: lead

Related Publications (11)

• Carmeli E, Imam B. Health promotion and disease prevention strategies in older adults with intellectual and developmental disabilities. Front Public Health. 2014 Apr 14;2:31. doi: 10.3389/fpubh.2014.00031. eCollection 2014.

  PMID: 24783190 BACKGROUND

• Erickson KI, Hillman C, Stillman CM, Ballard RM, Bloodgood B, Conroy DE, Macko R, Marquez DX, Petruzzello SJ, Powell KE; FOR 2018 PHYSICAL ACTIVITY GUIDELINES ADVISORY COMMITTEE*. Physical Activity, Cognition, and Brain Outcomes: A Review of the 2018 Physical Activity Guidelines. Med Sci Sports Exerc. 2019 Jun;51(6):1242-1251. doi: 10.1249/MSS.0000000000001936.

  PMID: 31095081 BACKGROUND

• Formenti D, Duca M, Trecroci A, Ansaldi L, Bonfanti L, Alberti G, Iodice P. Perceptual vision training in non-sport-specific context: effect on performance skills and cognition in young females. Sci Rep. 2019 Dec 10;9(1):18671. doi: 10.1038/s41598-019-55252-1.

  PMID: 31822740 BACKGROUND

• Forte R, Trentin C, Tocci N, Lucia S, Aydin M, Di Russo F. Motor-cognitive exercise with variability of practice and feedback improves functional ability and cognition in older individuals. Aging Clin Exp Res. 2023 Nov;35(11):2797-2806. doi: 10.1007/s40520-023-02568-8. Epub 2023 Oct 19.

  PMID: 37853304 BACKGROUND

• Giuliani F, Favrod J, Grasset F, Schenk F. Accurate memory for object location by individuals with intellectual disability: absolute spatial tagging instead of configural processing? Res Dev Disabil. 2011 May-Jun;32(3):986-94. doi: 10.1016/j.ridd.2011.01.055. Epub 2011 Feb 24.

  PMID: 21353464 BACKGROUND

• Henderson JM. Human gaze control during real-world scene perception. Trends Cogn Sci. 2003 Nov;7(11):498-504. doi: 10.1016/j.tics.2003.09.006.

  PMID: 14585447 BACKGROUND

• Horner-Johnson W, Bailey D. Assessing Understanding and Obtaining Consent from Adults with Intellectual Disabilities for a Health Promotion Study. J Policy Pract Intellect Disabil. 2013 Sep;10(3):10.1111/jppi.12048. doi: 10.1111/jppi.12048.

  PMID: 24223054 BACKGROUND

• Krahn GL, Fox MH. Health disparities of adults with intellectual disabilities: what do we know? What do we do? J Appl Res Intellect Disabil. 2014 Sep;27(5):431-46. doi: 10.1111/jar.12067. Epub 2013 Jul 31.

  PMID: 23913632 BACKGROUND

• Santos FH, Zurek J, Janicki MP. Efficacy of Healthy Aging Interventions for Adults With Intellectual and Developmental Disabilities: A Systematic Review. Gerontologist. 2022 Apr 20;62(4):e235-e252. doi: 10.1093/geront/gnaa192.

  PMID: 33220058 BACKGROUND

• Wollesen B, Wildbredt A, van Schooten KS, Lim ML, Delbaere K. The effects of cognitive-motor training interventions on executive functions in older people: a systematic review and meta-analysis. Eur Rev Aging Phys Act. 2020 Jul 2;17:9. doi: 10.1186/s11556-020-00240-y. eCollection 2020.

  PMID: 32636957 BACKGROUND

• Cavaggioni L, Formenti D, Castiglioni P, Ardigo LP, Merati G. Perceptual-vision training as a strategy for healthy aging in adults with intellectual disability: a study protocol. Front Psychol. 2025 Apr 24;16:1526826. doi: 10.3389/fpsyg.2025.1526826. eCollection 2025.

  PMID: 40342338 DERIVED

MeSH Terms

Conditions

Intellectual Disability; Motor Activity

Interventions

Control Groups

Condition Hierarchy (Ancestors)

Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Neurodevelopmental Disorders; Mental Disorders; Behavior

Intervention Hierarchy (Ancestors)

Epidemiologic Research Design; Epidemiologic Methods; Investigative Techniques; Research Design; Methods

Study Officials

• Luca Cavaggioni, PhD

  Universitià degli Studi dell'Insubria

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: October 3, 2024
• First Posted: October 8, 2024
• Study Start: May 5, 2025
• Primary Completion: October 28, 2025
• Study Completion: December 31, 2025
• Last Updated: May 6, 2026

Record last verified: 2024-10