High-intensity Interval Training and Vitamin D Effects on Bone Metabolism Among Women Diagnosed With Osteoporosis

NCT06624657 | Completed

• 1 other identifier: RRC-2016-028
• Study Type: observational
• Target: 120
• Locations: 0 countries
• Sites: N/A

Brief Summary

The effects of 16-week high-intensity interval training (HIIT) and vitamin D supplements on bone mineral density (BMD) in women with osteoporosis. The participants assigned for HITT exercise training with or without vitamin D supplements for 16 weeks, and the levels of serum bone parameters like, Osteocalcin (OC), Ca, and s-BAP were estimated in women with osteoporosis at baseline and after post-training interventions. In addition, the levels of Vitamin D were also identified in all women's accordingly.

Conditions

Osteoporosis; Exercise Overtraining; Vitamin D 25-Hydroxylase Deficiency

Keywords

Exercise training, BMD, osteoporosis, Vitamin D deficiency

Outcome Measures

Primary Outcomes (1)

• Anthropometric measurements

  BMI measurements were evaluated

  4 month

Secondary Outcomes (2)

• Assessments of bone mineral density (BMD)

  4 month

• Assessments of bone serum markers and vitamin 25(OH) D

  4 month

Study Arms (4)

control group

Participants are women with osteoporosis Characterized by normal daily activities and diets

Other: vitamin D supplements fo 16 weks

Exercise group

Participants are women's with osteoporosis participated in HIIT-exercise program interventions for 16 weeks

Other: vitamin D supplements fo 16 weks

Vitamin D group

Participants are women's with osteoporosis who received vitamin D 800IU/ day for 16 weeks

Other: vitamin D supplements fo 16 weks

Concurrent group

Participants are women's with osteoporosis who shared for HIIT exercise program plus vitamin D for 16 weeks

Other: vitamin D supplements fo 16 weks

Interventions

vitamin D supplements fo 16 weks OTHER

subjects exercised by HIIT-exercise for 16 weeks

Also known as: HIIT-exercise for 16 weeks

Concurrent group; Exercise group; Vitamin D group; control group

Eligibility Criteria

• Age: 30 Years - 50 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

a healthy, no-smoking premenopausal women aged (30-50) years old subjects who diagnosed with osteoporosis based on the clinical features and diagnosis evidence of bone mineral density (BMD) measured from both lumbar spine L2 to L4, and from the right and left sides of the hip region by Dual Energy X-ray Absorptiometry (DEXA, UNIGAMMA PLUS AC 230V 50/60Hz 400w, USA) scan method were invited to participate in this study

You may qualify if:

• A healthy non-smoker premenopausal women's
• Age are 30-50 years old
• subjects who diagnosed with osteoporosis based on the clinical features of bone mineral density (BMD) measured from both lumbar spine L2 to L4, and from the right and left sides of the hip region by Dual Energy X-ray Absorptiometry (DEXA, UNIGAMMA PLUS AC 230V 50/60Hz 400w, USA) scan method.

You may not qualify if:

• Women with; physical disability,
• abnormal hormonal levels
• severe disease complications such as chronic kidney and liver diseases,
• rheumatoid and osteoarthritis diseases
• significant overweight (BMI ≥25) and obesity (≥30 kg/m2) per recommended by the World Health Organization
• history of receiving calcium, multivitamin supplements, corticosteroids, anticonvulsants, and heparin which might affects up on the assessment of bone markers and BMD measurements were excluded from this study.

Sponsors & Collaborators

• King Saud University: lead

Related Publications (1)

• Alghadir AH, Gabr SA, Iqbal A. Concurrent effects of high-intensity interval training and vitamin D supplementation on bone metabolism among women diagnosed with osteoporosis: a randomized controlled trial. BMC Musculoskelet Disord. 2025 Apr 21;26(1):381. doi: 10.1186/s12891-025-08275-x.

  PMID: 40259289 DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

Height, weight, BMI measurements, Serum levels of vitamin 25(OH) D, osteocalcin, s-BAP, and calcium ,and, BMD of the lumbar spine (L2-L4) and hip were identified in subjects of all groups pre ad post HIIT and vitamin D supplementation for 16 weeks

MeSH Terms

Conditions

Osteoporosis; Overtraining Syndrome; Vitamin D Hydroxylation-Deficient Rickets, Type 1B; Vitamin D Deficiency

Condition Hierarchy (Ancestors)

Bone Diseases, Metabolic; Bone Diseases; Musculoskeletal Diseases; Metabolic Diseases; Nutritional and Metabolic Diseases; Fatigue; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Avitaminosis; Deficiency Diseases; Malnutrition; Nutrition Disorders

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: King Saud University

Study Record Dates

• First Submitted: September 29, 2024
• First Posted: October 3, 2024
• Study Start: July 15, 2016
• Primary Completion: March 30, 2017
• Study Completion: May 25, 2017
• Last Updated: December 27, 2024

Record last verified: 2024-12

Data Sharing

• IPD Sharing: Will not share