Dynamic Light Scattering Ocular Measurement in the Detection of Dementia

NCT06613971 | Recruiting DMC

• 1 other identifier: ACRM2024003
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

This is a human clinical study making a noninvasive measurement from a patient's eye to determine whether there is a quantitative difference in measurements between patients with and without the diagnosis of dementia.

Conditions

Dementia; Dementia Alzheimer Type

Keywords

Dementia; Spectroscopy; Dynamic Light Scattering Spectroscopy; Retinal Nerve Fiber Layer; DLS

Outcome Measures

Primary Outcomes (1)

• Comparison of Dynamic Light Scattering Spectroscopy in Dementias

  Dynamic light scattering will be compared between patients with dementias and patients with no cerebral pathology.

  Single measurement taken over 5 minutes

Study Arms (2)

Patients diagnosed with dementia

Patients diagnosed with dementia including those caused by Alzheimer's, Vascular, Lewy body, Mixed, Parkinson's, Frontotemporal, Creutzfeldt-Jakob, Normal pressure hydrocephalus, Huntington's, Wernicke-Korsakoff Syndrome.

Patients without cerebral pathology

Patients without cerebral pathology (no dementia)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Diagnostic radiology practice

1. All patients must be capable of an adequate ophthalmic evaluation and testing. This includes the ability to cooperate with the exam, sufficiently clear media (cornea, lens, vitreous) and sufficient pupillary dilation. 2. Patients must be capable of providing informed consent. 3. Patients who are not medically stable or who may be at significant risk to their health will not be eligible. 4. Women of child bearing age must not be pregnant at the time of examination.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• MD Stem Cells: lead
• Jeffrey N Weiss MD: collaborator
• 3T Radiology: collaborator
• The Healing Institute: collaborator

Study Sites (1)

3T Radiology

Coconut Creek, Florida, 33073, United States

RECRUITING

MeSH Terms

Conditions

Dementia; Alzheimer Disease

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurocognitive Disorders; Mental Disorders; Tauopathies; Neurodegenerative Diseases

Study Officials

• Jeffrey N Weiss, MD

  The Healing Institute

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Jeffrey N Weiss, MD

CONTACT

954-608-7604; jweissmd@me.com

Daryl Eber, MD

CONTACT

954-686-2559; dreber@3tradiology.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 23, 2024
• First Posted: September 26, 2024
• Study Start: April 25, 2024
• Primary Completion (Estimated): April 25, 2027
• Study Completion (Estimated): April 25, 2028
• Last Updated: May 8, 2025

Record last verified: 2024-09

Locations

US (1)