University of Central Florida Music Study

NCT07306065 | Recruiting

• 1 other identifier: STUDY00007771
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to scientifically validate the impact of music therapy on Alzheimer's disease (AD) by analyzing molecular biomarkers in salivary exosomes. Exosomes are extracellular vesicles that carry molecular signals from brain cells, providing a non-invasive method to assess physiological changes.

Conditions

Alzheimers Disease; Dementia; Dementia Alzheimer Type

Keywords

Alzheimer s disease; music; dementia

Outcome Measures

Primary Outcomes (1)

• Effect of music therapy in Alzheimer's patients by analyzing salivary exosomes

  To determine the effect of music therapy on key neurochemical biomarkers in Alzheimer's patients by analyzing serotonin, dopamine, amyloid-beta, and tau protein levels in salivary exosomes before and after music therapy sessions.

  6 months

Secondary Outcomes (2)

• Identifying therapeutic benefits by correlating changes in biomarkers

  6 months

• Identify differences in individual participant biomarkers

  6 months

Study Arms (1)

All participants

EXPERIMENTAL

All participants in study will undergo music intervention.

Other: Music intervention

Interventions

Music intervention OTHER

UCF music concert where the participants will listen to symphonic, classical music for 1 hour.

All participants

Eligibility Criteria

• Age: 50 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• years old or older.
• adults with no mild-cognitive impairment
• adults with mild-cognitive impairment
• adults with Alzheimer's disease/ dementia.
• participant or the participant's legally authorized representative must be able to read or speak English and agree to comply with study procedures.
• pregnant women may chose to participate

You may not qualify if:

• years and younger
• prisoners
• unable to understand English and provide consent

Sponsors & Collaborators

• University of Central Florida: lead

Study Sites (1)

University of Central Florida

Orlando, Florida, 32827, United States

RECRUITING

MeSH Terms

Conditions

Alzheimer Disease; Dementia

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders

Study Officials

• Kiminobu Sugaya, PhD

  University of Central Florida

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Amoy Fraser, PhD, CCRP, PMP

CONTACT

14072668742; Amoy.Fraser@ucf.edu

Britney-Ann Wray, BS, CTBS, CCRP

CONTACT

4072668742; britney-ann.wray@ucf.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Masking Details: All participants will undergo the same intervention. Each participant will be assigned a participant ID. All research data will be associated with the participant ID only and not with any of the participant's personal identifiers.
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: The study intervention is music, which is being provided by a UCF music concert where the participants will listen to symphonic music.

Study Record Dates

• First Submitted: October 8, 2025
• First Posted: December 29, 2025
• Study Start: August 28, 2025
• Primary Completion: March 1, 2026
• Study Completion: March 1, 2026
• Last Updated: December 29, 2025

Record last verified: 2025-12

Locations

US (1)