Assessment of CXCL5 Level in SLE Patients and Its Correlation with Disease Activity

NCT06610409 | Not Yet Recruiting

• 1 other identifier: CXCL5 in SLE patients
• Study Type: observational
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

Assessment of CXCL5 biomarker in Serum of patients of SLE in comparison to healthy patients and its correlation with disease activity

Conditions

SLE (Systemic Lupus)

Outcome Measures

Primary Outcomes (2)

• To assess CXCL5 level in SLE patients compared to healthy controls

  2024 -2027

• To assess CXCL5 level in association with disease activity

  2024-2027

Study Arms (2)

SLE patients

Diagnostic Test: blood sampling

Healthy controls

Diagnostic Test: blood sampling

Interventions

blood sampling DIAGNOSTIC_TEST

Blood sample for CXCL5 Level

Healthy controls; SLE patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

50 SLE patients and 40 healthy controls

You may qualify if:

• Age \>18 years old
• Patients who are diagnosed as SLE according to the 2012 Systemic Lupus International Collaborating Clinics (SLICC) Citeria (10,11).

You may not qualify if:

• age \< 18 years old
• Patients unwilling to participate in the study.
• Patients with other autoimmune diseases.
• Patients with malignancy or infections.
• Pregnancy and lactation

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Faculty of medicine Assiut University

Asyut, Dairuit, Egypt

Location

Related Publications (2)

• Fan X, Ng CT, Guo D, Lim F, Tan JC, Law A, Goh LH, Poon ZY, Cheung A, Kong SL, Tan M, Li S, Loh A, James A, Lim T, Chen J, Thumboo J, Hwang W, Low A. Dampened Inflammation and Improved Survival After CXCL5 Administration in Murine Lupus via Myeloid and Neutrophil Pathways. Arthritis Rheumatol. 2023 Apr;75(4):553-566. doi: 10.1002/art.42383. Epub 2023 Feb 22.

  PMID: 36240108 BACKGROUND

• Zhang L, Zhao L, Du K, Chen J, Ding H, Petersen F, Ye S, Lin Z, Yu X. Serum levels of CXCL5 are decreased and correlate with circulating platelet counts in systemic lupus erythematosus. Int J Rheum Dis. 2024 Mar;27(3):e15089. doi: 10.1111/1756-185X.15089.

  PMID: 38439196 BACKGROUND

Biospecimen

Retention: SAMPLES WITHOUT DNA

Blood samples

MeSH Terms

Conditions

Lupus Erythematosus, Systemic

Interventions

Blood Specimen Collection

Condition Hierarchy (Ancestors)

Connective Tissue Diseases; Skin and Connective Tissue Diseases; Autoimmune Diseases; Immune System Diseases

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dairuit , Assuit

Study Record Dates

• First Submitted: September 20, 2024
• First Posted: September 24, 2024
• Study Start: October 1, 2024
• Primary Completion (Estimated): September 30, 2027
• Study Completion (Estimated): September 30, 2027
• Last Updated: September 24, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)