Tidal Volume Adjustment According to Forced Vital Capacity Versus Predicted Body Weight in Thoracic Surgery Patients

NCT06608602 | Completed

• 1 other identifier: TV01
• Study Type: observational
• Target: 140
• Locations: 1 country
• Sites: 2

Brief Summary

The goal of this observational study is to learn about the intraoperative and postoperative pulmonary effects of tidal volume adjustment according to force vital capacity in thoracic surgery patients. The main question it aims to answer is: Is there any positive effect of tidal volume adjustment according to force vital capacity on intraoperative and postoperative lung function in thoracic surgery patients? Participants already taking tidal volume adjustment according to force vital capacity or predicted body weight during toracic surgery. As part of the medical care of thoracic surgery patients, intraoperative hemodynamic variables, lung dynamics and blood gas values and postoperative pulmonary complications will be monitored.

Conditions

Tidal Volume; Thoracic Surgery; Forced Vital Capacity; Predicted Body Weight

Outcome Measures

Primary Outcomes (2)

• intraoperative oxygenation (PaO2/FiO2 ratio)

  The ratio of partial pressure of oxygen in arterial blood (PaO2) to the fraction of inspiratory oxygen concentration (FiO2) is an indicator of pulmonary shunt fraction.

  5 time during surgery (T1:after intubation on TLV, T2: after lateral position on TLV, T3: after 30 min onset OLV, T4: the end of OLV on TLV, T5: before extubation on TLV

• lung compliance (mL/cmH2O)

  static and dynamic compliance

  5 time during surgery (T1:after intubation on TLV, T2: after lateral position on TLV, T3: after 30 min onset OLV, T4: the end of OLV on TLV, T5: before extubation on TLV

Secondary Outcomes (2)

• postoperative pulmonary complications

  Through postoperative 5 days

• Length of hospital stay (day)

  Through postoperative period, an avarage of 5 days

Study Arms (1)

Group I and Group II

Group I= tidal volume 7 ml/predicted body weight Group II= tidal volume FVC/8 ml

Other: tidal volume adjustment during surgery

Interventions

tidal volume adjustment during surgery OTHER

tidal volume adjustment during surgery according to body weight or FVC

Group I and Group II

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

patients scheduled for elective thoracic surgery under general anesthesia

You may qualify if:

• Patients over 18 years of age
• American Society of Anesthesiologists (ASA) physical status I-III
• Scheduled for elective thoracic surgery under general anesthesia

You may not qualify if:

• Age over 18 years old,
• ASA \> III,
• Pregnancy,
• Presence of large bullae and/or pneumothorax,
• Previous lung resection surgery,
• Intensive care unit (ICU) admission in the preoperative period,
• Predictive postoperative ICU admission,
• Pneumonectomy surgery

Sponsors & Collaborators

• Cukurova University: lead

Study Sites (2)

Cukurova University Faculty of Medicine Anesthesiology Department

Adana, Adana, 01380, Turkey (Türkiye)

Location

Cukurova University Faculty of Medicine Anesthesiology Department

Adana, 01330, Turkey (Türkiye)

Location

Study Officials

• mediha Turktan, MD

  Cukurova University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: dr

Study Record Dates

• First Submitted: September 11, 2024
• First Posted: September 23, 2024
• Study Start: September 20, 2024
• Primary Completion: January 31, 2025
• Study Completion: January 31, 2025
• Last Updated: December 19, 2025

Record last verified: 2025-01

Locations

TU (2)