Upper Limb Muscle Strength Models for Patients With Motor Impairment.

NCT06608121 | Completed DMC

• 1 other identifier: 2024-A01007-40
• Study Type: interventional
• Target: 32
• Locations: 1 country
• Sites: 1

Brief Summary

Upper limb motor impairments are common. They affect quality of life and can lead to dependency. They are mainly due to neurological conditions such as stroke, multiple sclerosis, and traumatic spinal cord injury. However, the contractile properties of muscle, in particular the maximum force that can be generated voluntarily (MVF) depending on joint angle and motion speed, have been mainly studied and modeled in healthy people. This study aims at developing mathematical models describing residual muscle forces in patients with motor impairments. The knowledge could guide patients' rehabilitation and could be useful for the development of robotic assistance systems that use patients\' residual capacities to control the level of assistance provided.

Conditions

Stroke; Multiple Sclerosis; Spinal Cord Injuries

Keywords

muscle strength; modeling; upper limb; motor impairment

Outcome Measures

Primary Outcomes (1)

• Description of the residuals of the effort generation models, defined as the difference between the actual effort values and the modelled values: o Average residual of the models (mean ± standard deviation) (Main Evaluation Criterion)

  From enrollment to the end of the participation at maximum 7 days

Study Arms (1)

Experimental

EXPERIMENTAL

Other: Upper limb isokinetic forces measurements

Interventions

Upper limb isokinetic forces measurements OTHER

The trial is a single-center prospective interventional study. Patients aged 18 to 85 years hospitalized in a French rehabilitation center for stroke, multiple sclerosis or traumatic tetraplegia and presenting a motor deficit ≤3/5 at the shoulder and elbow will be included. MVF measurements will be performed using an isokinetic ergometer during a single session. Concentric and eccentric MVF, as well as the forces generated during passive motion, will be measured in shoulder external-internal rotation and in elbow flexion-extension, in the seated position. The demographic, anthropometric and medical data required for the study will be extracted from medical records. Patients' residual muscle strength will be described and modeled. Explanatory factors for model quality will be determined.

Experimental

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients aged between 18 and 85
• A patient who is a member or beneficiary of a social security scheme
• Patients hospitalised at the Saint-Hélier rehabilitation centre for a stroke more than 15 days old, MS or SCI
• Patients with a motor deficit ≤3/5 on the MRC (Medical Research Council) scale in both internal-external shoulder rotation and elbow flexion-extension.
• Patient with voluntary consent to participate in this study.

You may not qualify if:

• Spasticity \>3/4 on the Aschworth scale in the shoulder abductor or elbow flexor muscles.
• Cognitive impairment that may interfere with measurements (MOCA \< 20/30)
• Presence of a pressure sore \> stage 2 at the ischial level
• Recent trauma to limbs or spine
• Decompensated heart disease or other unbalanced pathology which contraindicates or may hinder isokinetic testing.
• Persons deprived of their liberty by a judicial or administrative decision
• Pregnant women, women in labour or nursing mothers.

Sponsors & Collaborators

• Pôle Saint Hélier: lead

Study Sites (1)

Fondation Saint-Hélier

Rennes, 35043, France

Location

Related Publications (1)

• Tomezzoli A, Cassard B, Leblong E, Hayter J, Anne C, Bodet L, Pontonnier C. Are Isokinetic Torque-Angle Models Derived from Healthy Subjects Applicable to Patients with Upper-Limb Neurological Motor Impairment? Ann Biomed Eng. 2026 Feb 22. doi: 10.1007/s10439-026-04041-9. Online ahead of print.

  PMID: 41724899 DERIVED

MeSH Terms

Conditions

Stroke; Multiple Sclerosis; Spinal Cord Injuries

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases; Spinal Cord Diseases; Trauma, Nervous System; Wounds and Injuries

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 19, 2024
• First Posted: September 23, 2024
• Study Start: November 5, 2024
• Primary Completion: October 22, 2025
• Study Completion: October 22, 2025
• Last Updated: December 3, 2025

Record last verified: 2025-12

Locations

FR (1)