Optic Nerve Sheath Ultrasound During Electroconvulsive Therapy

NCT06607679 | Completed

• 1 other identifier: 2022-05-03-123/26
• Study Type: observational
• Target: 39
• Locations: 1 country
• Sites: 1

Brief Summary

Electroconvulsive therapy (ECT) is an effective method that has been used for many years in the treatment of psychiatric disorders and is currently administered under general anesthesia. This study evaluated the effect of ECT on intracranial pressure by measuring the optic nerve sheath diameter (ONSD) using ultrasonography. The primary aim was to determine how ONSD values measured during the postictal period change compared to baseline values. Secondary objectives included identifying factors related to the participants and the ECT procedure that affect ONSD.

Conditions

Intracranial Pressure Change; Hypertension; Electroconvulsive Therapy Treated Patients

Keywords

Intracranial Pressure Change; Hypertension; Electroconvulsive Therapy

Outcome Measures

Primary Outcomes (1)

• Intracranial Pressure Changes During Electroconvulsive Therapy

  During electroconvulsive therapy, sequential measurements were conducted using ocular ultrasound. These measurements revealed significant changes in intracranial pressure during the post-seizure period compared to baseline values.

  45 MINUTES

Secondary Outcomes (1)

• Association Between ONSD Measurements And Comorbid Conditions

  45 MINUTES

Study Arms (1)

Patients Receiving ECT

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients admitted to the Psychiatry Clinic at the Faculty of Medicine, Cukurova University

You may qualify if:

• years and older
• ASA 1,2,3
• Participants with various psychiatric problems requiring ECT

You may not qualify if:

• Intracranial mass, edema, or bleeding observed on MRI scan
• previous eye surgery
• severe cataracts
• glaucoma
• optic atrophy
• other severe sight impairment
• traumatic brain injury, space-occupying, and inflammatory lesions

Sponsors & Collaborators

• İrem AKSOY: lead
• Cukurova University Medical Faculty Hospital: collaborator

Study Sites (1)

Cukurova University Faculty of Medicine Hospital

Adana, Sariçam, 01330, Turkey (Türkiye)

Location

Related Publications (10)

• Chawla N. Anesthesia for Electroconvulsive Therapy. Anesthesiol Clin. 2020 Mar;38(1):183-195. doi: 10.1016/j.anclin.2019.10.007. Epub 2020 Jan 3.

  PMID: 32008651 BACKGROUND

• Singh SK, Bhatia K. Ultrasonographic Optic Nerve Sheath Diameter as a Surrogate Measure of Raised Intracranial Pressure in Severe Pregnancy-induced Hypertension Patients. Anesth Essays Res. 2018 Jan-Mar;12(1):42-46. doi: 10.4103/aer.AER_218_17.

  PMID: 29628552 BACKGROUND

• Derikx RL, van Waarde JA, Verwey B, van der Mast RC. Effects on intracranial pressure of electroconvulsive therapy. J ECT. 2012 Jun;28(2):e23-4. doi: 10.1097/YCT.0b013e31824d9b69.

  PMID: 22622301 BACKGROUND

• Czosnyka M, Pickard JD. Monitoring and interpretation of intracranial pressure. J Neurol Neurosurg Psychiatry. 2004 Jun;75(6):813-21. doi: 10.1136/jnnp.2003.033126.

  PMID: 15145991 BACKGROUND

• Bouckaert F, Sienaert P, Obbels J, Dols A, Vandenbulcke M, Stek M, Bolwig T. ECT: its brain enabling effects: a review of electroconvulsive therapy-induced structural brain plasticity. J ECT. 2014 Jun;30(2):143-51. doi: 10.1097/YCT.0000000000000129.

  PMID: 24810772 BACKGROUND

• Andrade C, Bolwig TG. Electroconvulsive therapy, hypertensive surge, blood-brain barrier breach, and amnesia: exploring the evidence for a connection. J ECT. 2014 Jun;30(2):160-4. doi: 10.1097/YCT.0000000000000133.

  PMID: 24800688 BACKGROUND

• Perera TD, Luber B, Nobler MS, Prudic J, Anderson C, Sackeim HA. Seizure expression during electroconvulsive therapy: relationships with clinical outcome and cognitive side effects. Neuropsychopharmacology. 2004 Apr;29(4):813-25. doi: 10.1038/sj.npp.1300377.

  PMID: 14735129 BACKGROUND

• Baghai TC, Moller HJ. Electroconvulsive therapy and its different indications. Dialogues Clin Neurosci. 2008;10(1):105-17. doi: 10.31887/DCNS.2008.10.1/tcbaghai.

  PMID: 18472488 BACKGROUND

• Dubourg J, Javouhey E, Geeraerts T, Messerer M, Kassai B. Ultrasonography of optic nerve sheath diameter for detection of raised intracranial pressure: a systematic review and meta-analysis. Intensive Care Med. 2011 Jul;37(7):1059-68. doi: 10.1007/s00134-011-2224-2. Epub 2011 Apr 20.

  PMID: 21505900 BACKGROUND

• Andrade C, Arumugham SS, Thirthalli J. Adverse Effects of Electroconvulsive Therapy. Psychiatr Clin North Am. 2016 Sep;39(3):513-30. doi: 10.1016/j.psc.2016.04.004. Epub 2016 Jun 25.

  PMID: 27514303 BACKGROUND

MeSH Terms

Conditions

Hypertension

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases

Study Officials

• Demet Laflı Tunay, Associate Professor

  Department of Anesthesiology and Reanimation, Çukurova University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Consultant Anesthesiologist

Study Record Dates

• First Submitted: September 19, 2024
• First Posted: September 23, 2024
• Study Start: June 3, 2022
• Primary Completion: November 23, 2022
• Study Completion: November 23, 2022
• Last Updated: February 25, 2025

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF
• Time Frame: Beginning 1 year after publication with no end date.

Locations

TU (1)