Predictive Effect of Abdominal Fat and Muscle Area Calculated Based on Abdominal CT on Gastric Cancer Patients

NCT06606912 | Active Not Recruiting DMC

• 1 other identifier: ZZ2024-158-01
• Study Type: observational
• Target: 4,000
• Locations: 1 country
• Sites: 3

Brief Summary

This study aims to create a clinical prediction model. Abdominal fat and muscle area also play an important role in the prediction of surgical outcomes in colorectal cancer. Studies have shown that excess visceral fat and low skeletal muscle mass (sarcopenia) are associated with poorer postoperative outcomes, including a higher risk of postoperative complications and lower survival. Preoperative imaging techniques such as CT, MRI and ultrasound that provide accurate measurements to assess abdominal fat and muscle area can help surgeons develop individualized surgical and rehabilitation plans, improve surgical success, reduce complications and improve long-term patient prognosis. In this study, the investigators expected to construct a prediction model of abdominal fat and muscle area on the short- and long-term outcomes of gastric and colorectal cancer patients by calculating the abdominal fat and muscle area in different levels of abdominal CT images, in order to further adjust and guide the treatment plan.

Conditions

Gastric Cancers; Colorectal Cancer; Sarcopenia; Obesity and Overweight

Keywords

Subcutaneous Fat; Visceral fat; gastrointestinal cancer; sarcopenia; surgery

Outcome Measures

Primary Outcomes (1)

• Overall survival

  Overall survival was defined as time from date of diagnosis until the date of death from any cause or or loss to follow-up.

  From date of diagnosis until the date of death from any cause or or loss to follow-up, whichever came first, assessed up to 60 months

Secondary Outcomes (1)

• Rate of postoperative complications

  From date of surgery until the date of first documented postoperative complication, assessed up to 2 months after surgery.

Interventions

Skeletal muscle, subcutaneous fat and visceral fat area OTHER

CT-based measurement of skeletal muscle, subcutaneous fat and visceral fat areas at L1, L2, L3, L4 and L5 levels.

Also known as: Sarcopenia, obesity, overweight

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All adult patients diagnosed with gastric and colorectal cancer and undergoing radical surgery for gastric and colorectal cancer at the study centre.

You may qualify if:

• Diagnosis of gastric cancer or colorectal cancer confirmed by pathology or cytology;
• aged \>18 years;
• not received chemotherapy, radiotherapy, targeted therapy or immunotherapy;
• post-operative pathological stages other than stage IV, or no liver, lung or other organs as confirmed by CT, MRI, B-ultrasound imaging.
• patients who have pre-operative CT examination data kept in our hospital.

You may not qualify if:

• Poor quality of preoperative CT images;
• refusal to participate in this study.

Sponsors & Collaborators

• First Affiliated Hospital of Chongqing Medical University: lead
• The Second Affiliated Hospital of Chongqing Medical University: collaborator
• Chongqing Medical University: collaborator

Study Sites (3)

the First Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, 400016, China

Location

the Second Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, 400016, China

Location

The Affiliated Yongchuan Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, 402160, China

Location

Related Publications (3)

• Han J, Liu X, Tang M, Yang F, Ding Z, Wu G. Abdominal fat and muscle distributions in different stages of colorectal cancer. BMC Cancer. 2023 Mar 28;23(1):279. doi: 10.1186/s12885-023-10736-2.

  PMID: 36978044 BACKGROUND

• Sun J, Lv H, Zhang M, Li M, Zhao L, Zeng N, Liu Y, Wei X, Chen Q, Ren P, Liu Y, Zhang P, Yang Z, Zhang Z, Wang Z. The Appropriateness Criteria of Abdominal Fat Measurement at the Level of the L1-L2 Intervertebral Disc in Patients With Obesity. Front Endocrinol (Lausanne). 2021 Dec 14;12:784056. doi: 10.3389/fendo.2021.784056. eCollection 2021.

  PMID: 34970225 BACKGROUND

• Koh H, Hayashi T, Sato KK, Harita N, Maeda I, Nishizawa Y, Endo G, Fujimoto WY, Boyko EJ, Hikita Y. Visceral adiposity, not abdominal subcutaneous fat area, is associated with high blood pressure in Japanese men: the Ohtori study. Hypertens Res. 2011 May;34(5):565-72. doi: 10.1038/hr.2010.271. Epub 2011 Jan 13.

  PMID: 21228782 BACKGROUND

MeSH Terms

Conditions

Stomach Neoplasms; Colorectal Neoplasms; Sarcopenia; Obesity; Overweight; Gastrointestinal Neoplasms

Interventions

Adiposity

Condition Hierarchy (Ancestors)

Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Stomach Diseases; Intestinal Neoplasms; Colonic Diseases; Intestinal Diseases; Rectal Diseases; Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight

Intervention Hierarchy (Ancestors)

Body Fat Distribution; Body Weights and Measures; Body Constitution; Physical Examination; Diagnostic Techniques and Procedures; Diagnosis; Body Composition; Biochemical Phenomena; Chemical Phenomena; Metabolism; Physiological Phenomena

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr.

Study Record Dates

• First Submitted: September 16, 2024
• First Posted: September 23, 2024
• Study Start: January 1, 2012
• Primary Completion: January 1, 2024
• Study Completion: December 31, 2024
• Last Updated: September 23, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will not share

Locations

CN (3)