Prone Position Assessed by 3D EIT

NCT07083973 | Recruiting

• 1 other identifier: Prone position by 3D-EIT
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

To investigate global and regional changes in lung ventilation and perfusion induced by prone position in ARDS patients assessed by 3D-EIT. And to investigate the difference between 2D-EIT and 3D-EIT in prone position monitoring.

Conditions

ARDS (Acute Respiratory Distress Syndrome); Respiratory Failure

Outcome Measures

Primary Outcomes (3)

• Regional ventilation monitored by EIT

  Using EIT to monitor the regional ventilation during supine and prone position, to monitor the ventilation distribution change.

  5-10minutes

• Regional perfusion monitored by EIT

  Using EIT to monitor the regional perfusion during supine and prone position, to monitor the ventilation distribution change.

  5-10minutes

• V/Q monitored by EIT

  Ventilation and perfusion monitored by EIT in supine and prone position. To evaluate the V/Q match, deadspace and shunt lung region.

  5-10minutes

Secondary Outcomes (2)

• Respiratory system compliance

  1 day

• SpO2

  1 day

Interventions

Prone position BEHAVIORAL

Patients were ventilated based on the ARDS-Net recommendations . Patients were kept in a supine position. The process of lung ventilation and perfusion assessment was as follows: 1. PEEP was determined by the attending doctor and was kept the same during the supine and prone period. 2. 3D-EIT was used to monitor the ventilation and perfusion of ARDS patients at three timepoints: T1: supine position, T2: prone position at 30min, T3: prone position over 10 hours.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with ARDS on mechanical ventilation

You may qualify if:

• patients on mechanical ventilation.
• Diagnosis of ARDS was based on the Berlin definition
• Patients in need of prone position because of clinical condition

You may not qualify if:

• Under 18 years of age.
• Pregnant women;
• Ribcage malformation
• Any contraindication to the use of EIT (e.g. automatic implantable cardioverter defibrillator, and implantable pumps).

Sponsors & Collaborators

• Peking Union Medical College Hospital: lead

Study Sites (1)

Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences

Beijing, Beijing Municipality, 100730, China

RECRUITING

MeSH Terms

Conditions

Acute Lung Injury; Respiratory Insufficiency

Interventions

Prone Position

Condition Hierarchy (Ancestors)

Lung Injury; Lung Diseases; Respiratory Tract Diseases; Respiration Disorders

Intervention Hierarchy (Ancestors)

Posture; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Central Study Contacts

Huaiwu He

CONTACT

01069152301; tjmuhhw@163.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 14, 2024
• First Posted: July 24, 2025
• Study Start: October 31, 2024
• Primary Completion (Estimated): October 31, 2026
• Study Completion (Estimated): December 30, 2026
• Last Updated: January 26, 2026

Record last verified: 2026-01

Locations

CN (1)