Environmental Pollutants and Life Quality

NCT06591988 | Enrolling By Invitation

• 1 other identifier: 01/2024
• Study Type: observational
• Target: 608
• Locations: 1 country
• Sites: 1

Brief Summary

This study is part of the MISTRAL project, funded by the European Commission under the Horizon Europe Program, within the Work Programme 2021-2022 of Pillar II - Health Cluster on Environment and Health, which has the main objective of creating a cloud-based informatics platform for Health Impact Assessment analysis that, thanks to artificial intelligence, is able to simulate different clinical scenarios, economic and social, before and after the introduction of environmental risk mitigation policies, starting from data and evidence derived from case studies (several European cities) with different levels of exposure to environmental, health, geographical and socio-economic factors. The Project involves 11 partners distributed among Italy (Istituto Superiore di Sanità, Azienda Sanitaria Locale di Taranto, University of Bari, Politecnico di Bari, APS PLANET), Belgium (University of Hasselt), Poland (AGH-University of Technology and Science), Germany (Nuromedia), Spain (Ubitel), Greece (WINGS-ICT Solutions) and England (University of Oxford, University of Suffolk). Specifically, the ZEPHYR study is a cross-sectional (cross-sectional), population-based, multicenter survey. The centers involved are the ASL of Taranto with the Taranto City Single District (Coordinating Recruitment Center), the University of Hasselt, Belgium (Recruitment Center Hasselt Hospital Campus), and the University of Krakow, Poland (Rybnik University Hospital as recruitment center).

Conditions

Environment; Pollution Exposure; Mortality; Healthcare; Lifestyle Factors

Keywords

environmental pollutants; lifestyle; mortality; risk factors; public health; life expectancy

Outcome Measures

Primary Outcomes (2)

• QALY

  quality-adjusted life-year. QALY scores range from 1 (perfect health) to 0 (dead)

  baseline and 2 years

• DALY

  Disability Adjusted Life Years. Disability-adjusted life years (DALYs) are a measure of overall disease burden, expressed as the number of years lost due to ill-health, disability, or early death.

  baseline and 2 years

Interventions

Lifestyle factors BEHAVIORAL

introduction of environmental risk mitigation policies, from data and evidence from case studies (several European cities) with different levels of exposure to environmental, health, geographic, and socioeconomic factors.

Also known as: environmental risk mitigation policies

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The sampling frame will consist of the demographic dataset from regional health registries for each national unit. The survey will include children, adults, and the elderly, and probability sampling will be applied in each subpopulation, using a nearest neighbor matching algorithm and considering sex and age classes (5-year intervals) as matching covariates.

You may qualify if:

• Within the population of Taranto (southern Italy), healthy volunteer subjects will be recruited, and sampled from the following geographic areas of the city: the Tamburi district (an area presumably highly exposed to environmental pollutants), and the Talsano-Lama-San Vito district.

You may not qualify if:

• unhealthy subjects
• Taranto people residing outside the above areas

Sponsors & Collaborators

• Azienda Sanitaria Locale di Taranto: lead

Study Sites (1)

Local Health Authority of Taranto

Taranto, 74121, Italy

Location

Related Links

• MISTRAL project

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Target Duration: 3 Days
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: September 9, 2024
• First Posted: September 19, 2024
• Study Start: September 1, 2024
• Primary Completion: April 1, 2025
• Study Completion: October 1, 2025
• Last Updated: September 19, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will not share

Locations

IT (1)