Preoperative Gluteal Muscle Atrophy: A Silent Predictor of THA Dislocation.

NCT06571604 | Completed

• 1 other identifier: THAdislocation glutealatrophy
• Study Type: observational
• Target: 72
• Locations: 1 country
• Sites: 1

Brief Summary

This study looks at how fat buildup in hip muscles relates to hip osteoarthritis and less favorable recovery after hip replacement surgery. While it is known that weak gluteal muscles might cause problems, it is not yet proven if this specifically leads to hip dislocation after surgery. The goal of this study is to compare fat buildup in gluteal muscles between patients who had a hip dislocation soon after surgery and those who did not.

Conditions

Dislocation; Total Hip Arthroplasty; Muscle Degeneration

Keywords

Total Hip Arthroplasty; Muscle Fatty Degeneration; CT; Gluteal Muscles

Outcome Measures

Primary Outcomes (1)

• Mean Attenuation Ratio

  The mean attenuation ratio (MAR), representing muscle fat degeneration, corresponds to the mean grayscale pixels in the selected area, expressed in Hounsfield Units (HU). Subsequently, the segmentation process was applied, selectively retaining pixels within the range of -30 HU to 150 HU. This range corresponds to muscle fibers and intramuscular fat, effectively excluding extra-fascial fat and bone pixels.

  The CT scan of the pelvis used to plan the operation is performed between one and two months before the surgery.

Secondary Outcomes (2)

• Cross-Sectional Area

  The CT scan of the pelvis used to plan the operation is performed between one and two months before the surgery.

• Intramuscular Fatty Fraction

  The CT scan of the pelvis used to plan the operation is performed between one and two months before the surgery.

Study Arms (2)

Dislocation group

Patients who underwent primary total hip arthroplasty with preoperative CT-scan and encountered an episode of dislocation.

Diagnostic Test: Dislocation

Control group

Patients underwent primary total hip arthroplasty with preoperative CT-scan, who did not experience any episodes of dislocation within two years post-surgery, adhering to the previously outlined exclusion criteria (group control).

Diagnostic Test: No dislocation

Interventions

Dislocation DIAGNOSTIC_TEST

One episode of total hip dislocation diagnozied on Xray within 2 years of surgery

Dislocation group

No dislocation DIAGNOSTIC_TEST

No experience of dislocation within two years post-surgery

Control group

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients following THA at Nimes university hospital

You may qualify if:

• primary THA with preoperative CT-scan

You may not qualify if:

• malposition of acetabular implants outside the Lewinneck safe zone,
• neurological or cognitive disorders,
• associated spinal pathologies (within the context of a hip-spine syndrome),
• chronic alcoholism,
• aseptic osteonecrosis,
• revision surgeries,
• late dislocations attributed to polyethylene wear,
• replacement following post-traumatic coxarthrosis due to acetabulum injuries.
• diameters of the prosthetic heads ≠ 32mm

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Nīmes: lead

Study Sites (1)

CHU Nîmes

Nîmes, Gard, 30900, France

Location

MeSH Terms

Conditions

Joint Dislocations

Condition Hierarchy (Ancestors)

Joint Diseases; Musculoskeletal Diseases; Wounds and Injuries

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 23, 2024
• First Posted: August 26, 2024
• Study Start: January 1, 2020
• Primary Completion: March 1, 2021
• Study Completion: May 1, 2023
• Last Updated: August 26, 2024

Record last verified: 2024-08

Locations

FR (1)