Cardiovascular and Metabolic Sciences Biorepository

NCT06560424 | Recruiting

• 1 other identifier: 24-708
• Study Type: observational
• Target: 10,000
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of the Cardiovascular and Metabolic Sciences Biorepository is to collect and store information and biospecimens (blood, urine, stool, and heart tissue) from patients with and without cardiovascular and metabolic diseases to create a readily available biorepository of samples and related medical health information to expedite future research into the causes and consequences of cardiovascular and metabolic diseases.

Conditions

Cardiovascular Diseases; Metabolic Disease

Keywords

Biorepository

Outcome Measures

Primary Outcomes (1)

• Number of samples enrolled per year

  Establish a biorepository of samples (blood, urine, stool, and heart tissue) and related medical health information to support future investigation into cardiovascular and metabolic diseases.

  Yearly through study completion (approximately 30 years)

Study Arms (3)

Personal History of Cardiovascular or Metabolic Diseases

Persons who have a diagnosis of a cardiovascular or metabolic disease. Examples of cardiovascular diseases are: heart failure, arrhythmias, high cholesterol, coronary artery disease, heart attack, and stroke. Examples of metabolic diseases are: diabetes, metabolic syndrome, and hemochromatosis.

Family History of Cardiovascular or Metabolic Diseases

Persons without a personal diagnosis of any cardiovascular or metabolic disease but with a family history in a first-degree relative of one of those diseases.

Healthy Controls

No personal or family (first-degree relative) history of cardiovascular or metabolic diseases.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

We will enroll persons with diagnosed cardiovascular or metabolic disease(s), persons with a family history of cardiovascular and/or metabolic disease(s), and persons without known cardiovascular or metabolic disease(s). The targeted number of participants to be enrolled is indefinite.

You may qualify if:

• Willing and able to sign the informed consent document

You may not qualify if:

• Chronic anemia (hemoglobin consistently \<9 g/L)

Sponsors & Collaborators

• The Cleveland Clinic: lead

Study Sites (1)

Cleveland Clinic Main Campus

Cleveland, Ohio, 44195, United States

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Blood (plasma, serum, whole blood, and/or PBMCs), urine, stool, and/or heart tissue samples.

MeSH Terms

Conditions

Cardiovascular Diseases; Metabolic Diseases

Condition Hierarchy (Ancestors)

Nutritional and Metabolic Diseases

Study Officials

• W. H. Wilson Tang, MD

  The Cleveland Clinic

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Jennifer Wilcox, BA

CONTACT

216-636-6153; kirsopj@ccf.org

Tim Engelman, LPN

CONTACT

216-636-6153; engelmt@ccf.org

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Staff Physician, Principal Investigator

Study Record Dates

• First Submitted: August 13, 2024
• First Posted: August 19, 2024
• Study Start: September 18, 2024
• Primary Completion (Estimated): December 31, 2050
• Study Completion (Estimated): December 31, 2050
• Last Updated: October 15, 2025

Record last verified: 2025-10

Locations

US (1)