The Effect of Magnesium Deficiency on Transforaminal Epidural Steroid Injection Success: An Observational Study

NCT06551792 | Completed

• 1 other identifier: KanuniSS
• Study Type: observational
• Target: 118
• Locations: 1 country
• Sites: 1

Brief Summary

Transforaminal epidural steroid injection (TFESE) is an interventional method frequently used in the treatment of radicular pain due to disc herniation. TFESE, which is applied under sterile conditions and under fluoroscopy guidance, increases its effectiveness when applied in the early period (first 3 months). Inflammation and increase in neurotransmitters in the nerve root due to disc herniation trigger pain. Steroids and local anesthetics applied to the nerve root with TFESE exhibit strong anti-inflammatory effects. Factors affecting the success of TFESE include the type and dose of drugs, the age of the patient, any accompanying comorbidities, the level of injection administered and other musculoskeletal problems. Studies on the effect of these parameters on the effectiveness of TFESE are limited.Cardiac arrhythmia, muscle spasms, tetany, fasciculation paresthesia, widespread body pain, impaired bone mineralization, electrolyte disorders such as hypokalemia, hypocalcemia, hypophosphatemia, depression, and seizures may occur due to magnesium deficiency. One of the most important causes of low back pain is degenerative disc disease, and magnesium deficiency has been shown to be associated with low back pain.

Conditions

Pain, Back

Keywords

pain,magnesium level, disc herniation

Outcome Measures

Primary Outcomes (1)

• Numeric Rating Scale-11 (NRS-11)

  It is an 11-point scale used to describe pain. It is based solely on the patient ability to perform activities of daily living and can be used for adults and children ages 10 and older.

  3 months

Secondary Outcomes (1)

• Oswestry Disability Index

  3 months

Study Arms (1)

Effect of Serum Magnesium Level on the Success of Transforaminal Epidural Steroid Injection

Transforaminal Epidural Steroid Injection groups

Other: Effect of Serum Magnesium Level on the Success of Transforaminal Epidural Steroid Injection

Interventions

Effect of Serum Magnesium Level on the Success of Transforaminal Epidural Steroid Injection OTHER

Effect of Serum Magnesium Level on the Success of Transforaminal Epidural Steroid Injection

Effect of Serum Magnesium Level on the Success of Transforaminal Epidural Steroid Injection

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Inclusion Criteria: * Patients with paracentral/subarticular protruded disc herniation who underwent transforaminal epidural steroid injection (TFESE) to the lumbosacral region * Patients with complete data to be scanned in their files

You may not qualify if:

• Patients whose medical analgesic treatment was changed during their three-month follow-up;
• Those with fibromyalgia;
• Those with metabolic diseases (chronic renal failure, spondyloarthropathies, diabetes, hypo/hyperthyroidism, etc.) that may affect serum magnesium level;
• Those with a history of lumbar surgery;
• those taking magnesium or calcium supplements;
• Those with malignancy or obesity;
• Those with psychiatric illness;
• Those without lumbar MRI; Patients whose clinical, physical examination and laboratory data cannot be accessed

Sponsors & Collaborators

• Kanuni Sultan Suleyman Training and Research Hospital: lead

Study Sites (1)

Kanuni Sultan Süleyman Training and Research Hospital

Istanbul, 34000, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Back Pain; Intervertebral Disc Displacement

Condition Hierarchy (Ancestors)

Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Spinal Diseases; Bone Diseases; Musculoskeletal Diseases; Hernia; Pathological Conditions, Anatomical

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: pain specialist

Study Record Dates

• First Submitted: April 24, 2024
• First Posted: August 13, 2024
• Study Start: June 1, 2024
• Primary Completion: August 30, 2024
• Study Completion: September 15, 2024
• Last Updated: December 12, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)