Pre-exercise Ingestion of a Low Glycaemic Index Rice-based Mixed Meal Increases Fat Oxidation and Endurance Running in a Hot-humid Environment

NCT06544252 | Completed DMC

• 1 other identifier: USM/JEPeM/19010083
• Study Type: interventional
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

The objective of this research is to determine the influence of low and high glycemic index Malaysian pre-exercise mixed meals on endurance exercise performance in a hot-humid environment. Glycemic index (GI) is a method used to classify CHO-containing foods based on their influence on postprandial blood glucose when compared to the response on blood glucose after ingesting the same amount of CHO from a reference food (glucose or bread). Low GI (LGI) foods are digested and absorbed more slowly as compared to high GI (HGI) foods, resulting in a stable rise in blood glucose levels. The participants were trained male endurance long-distance runners. On the day of experimental trials, they consumed pre-exercise rice-based mixed meal, either LGI or HGI 3 hours before endurance running exercise. After that, they ran for 45 minutes at constant running speed equivalent to 70% VO2peak, followed by 10km time-trial. The respiratory gases, blood measures, rectal and skin temperature were measured throughout the running test.

Conditions

Healthy; Trained Athletes

Outcome Measures

Primary Outcomes (1)

• Time to complete 10 km time-trial

  The participant was clearly instructed to complete the 10 km time-trial as quickly as possible. The 10 km time-trial commenced with a 30-s rolling start to the participant's 70% V̇O2peak speed, after which the participant could freely adjust the speed. Throughout the 10 km time-trial, the prevailing running velocity and time-lapse were blinded to the participant, and only information on the distance covered at 1 km intervals was verbally provided to the participant.

  Up to 1 hour

Secondary Outcomes (7)

• Fat and carbohydrate oxidation

  Up to 2 hours

• Capillary blood glucose

  Up to 5 hours

• Serum insulin

  Up to 5 hours

• Serum cortisol

  Up to 5 hours

• Serum lactate

  Up to 2 hours

Study Arms (2)

Low glycaemic index, Then high glycaemic index

EXPERIMENTAL

The participants were randomised to receive pre-exercise low glycaemic index rice-based mixed meal followed by a cross-over with the high glycaemic index rice-based mixed meal after one week

Dietary Supplement: Low glycaemic index rice-based mixed meal (GI value = 47); Dietary Supplement: High glycaemic index rice-based mixed meal (GI value = 80)

High glycaemic index, Then low glycaemic index

EXPERIMENTAL

The participants were randomised to receive pre-exercise high glycaemic index rice-based mixed meal followed by a cross-over with the low glycaemic index rice-based mixed meal after one week

Dietary Supplement: Low glycaemic index rice-based mixed meal (GI value = 47); Dietary Supplement: High glycaemic index rice-based mixed meal (GI value = 80)

Interventions

Low glycaemic index rice-based mixed meal (GI value = 47) DIETARY_SUPPLEMENT

The mixed meal consisted of Basmati rice, chicken, and green-leafy vegetables. The energy content of the mixed meal was based on the body mass of the participant. The amount of CHO was 1.3 g.kg-1 body mass (Burke et al. 2019), and the amount of protein given was 0.5 g.kg-1 per meal (Witard, Garthe and Phillips 2019).

High glycaemic index, Then low glycaemic index; Low glycaemic index, Then high glycaemic index

High glycaemic index rice-based mixed meal (GI value = 80) DIETARY_SUPPLEMENT

The mixed meal consisted of fragrant rice, chicken, and green-leafy vegetables.The energy content of the mixed meal was based on the body mass of the participant. The amount of CHO was 1.3 g.kg-1 body mass (Burke et al. 2019), and the amount of protein given was 0.5 g.kg-1 per meal (Witard, Garthe and Phillips 2019).

High glycaemic index, Then low glycaemic index; Low glycaemic index, Then high glycaemic index

Eligibility Criteria

• Age: 18 Years - 35 Years
• Gender Eligibility Details: Male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• healthy
• age 18-35 years old
• trained (peak oxygen consumption (V̇O2peak): ≥ 55 mL.kg-1.min-1)
• training volume (\>150 min, ≥ three times per week)
• competing at the national level
• \>2-year of running experience
• tier 2 (trained) or tier 3 (highly trained) runners (McKay et al. 2022)
• no allergies to any test foods

You may not qualify if:

• diagnosis of chronic diseases (i.e. diabetes mellitus, hypertension, cardiovascular disease)
• bone, muscle or joint impairments
• on medication
• currently smoking
• use of illicit drugs
• use of dietary supplements
• on any particular diet

Sponsors & Collaborators

• Universiti Sains Malaysia: lead

Study Sites (1)

Department of Community Health, Advanced Medical and Dental Institute

Kepala Batas, Pulau Pinang, 13200, Malaysia

Location

Study Officials

• Ahmad Munir Che Muhamed, PhD

  Department of Community Health, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, 13200, Kepala Batas, Pulau Pinang, Malaysia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principle Investigator

Model Details: The present study employed a randomised, single-blind, cross-over trial design consisting of two experimental trials separated by a one-week washout period to minimise carryover effects, conducted under hot-humid (32°C, 65% RH) conditions.. The participants were randomised into two groups, each comprising six participants. Six participants were randomised to receive low glycaemic index, and the other six participants received high glycaemic index pre-exercise dietary interventions, followed by a cross-over with the opposing dietary intervention after one week.

Study Record Dates

• First Submitted: July 25, 2024
• First Posted: August 9, 2024
• Study Start: January 1, 2022
• Primary Completion: January 30, 2023
• Study Completion: January 30, 2023
• Last Updated: August 9, 2024

Record last verified: 2024-08

Data Sharing

• IPD Sharing: Will not share

Locations

MY (1)