Decreasing Alzheimer's Risk Through oNline Choreographed Exercise - Down Syndrome

NCT06537648 | Completed Results

• 1 other identifier: T32AG078114
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators are assessing acceptability, appropriateness, and feasibility of an remote choreographed exercise intervention using validated scales alongside qualitative data among young adults with Down Syndrome. Participants will take part in a 12-week exercise program with two 35-minute session per week delivered in a group setting. The aims of the project are to:

• Assess the feasibility of a 12 week remotely delivered group dance intervention.
• Assess changes in aerobic fitness and cognitive function in response to a 12 week remotely delivered group dance intervention.
• Assess the intensity and total energy expenditure of remotely delivered group dance sessions.

Conditions

Down Syndrome; Physical Inactivity

Outcome Measures

Primary Outcomes (3)

• Attendance

  Attendance at each 35-minute online exercise classes will be collected. Attendance will be assessed as the number of sessions attended out of the total number of sessions available (24 sessions available).

  12 weeks

• Retention

  Participant retention will be collected based on the number of participants who complete the 12 week intervention. A total of up to 20 participants will be enrolled into the study. Participants that complete the 12-week intervention will be considered retained. Any participant that discontinues participation prior to the end of the 12-week intervention will not be considered retained.

  12 weeks

• Adverse Events

  Adverse events will be collected on a weekly basis.

  12 weeks

Secondary Outcomes (2)

• Energy Expenditure

  1 session

• Exercise Intensity

  12 weeks

Study Arms (1)

Decreasing Alzheimer's Risk Through oNline Choreographed Exercise - Down Syndrome

EXPERIMENTAL

Participants will be asked to attend 35 minute, remotely delivered, group exercise classes using choreographed exercise twice a week for 12 weeks.

Behavioral: Decreasing Alzheimer's Risk Through oNline Choreographed Exercise - Down Syndrome Program

Interventions

Decreasing Alzheimer's Risk Through oNline Choreographed Exercise - Down Syndrome Program BEHAVIORAL

Adults with Down syndrome will be asked to attend 35 minute, remotely delivered (Zoom®) group dance sessions twice weekly across 12 weeks. All sessions will be directed by an instructor experienced in leading 35 minute, group remote exercise sessions for individuals with intellectual disability as part of the ongoing exercise program for individuals with intellectual disability offered by the Division for Physical Activity and Weight Management.

Decreasing Alzheimer's Risk Through oNline Choreographed Exercise - Down Syndrome

Eligibility Criteria

• Age: 18 Years - 64 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Diagnosis of Down syndrome
• Sufficient functional ability to communicate through spoken language
• No plans to relocate outside the study area over the next 12 weeks
• Possession of a personal device that allows for connectivity to the internet and participate in 2x weekly group video calls
• Ability to participate in Moderate to vigorous physical activity

You may not qualify if:

• Serious medical risk (e.g., cancer, recent heart attack, stroke, pregnancy, angioplasty as determined by the research staff
• unwilling to participate in outcomes assessments
• uninterested

Sponsors & Collaborators

• University of Kansas Medical Center: lead

Study Sites (1)

University Of Kansas Medical Center

Kansas City, Kansas, 66160, United States

Location

MeSH Terms

Conditions

Down Syndrome; Sedentary Behavior

Condition Hierarchy (Ancestors)

Intellectual Disability; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Abnormalities, Multiple; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Chromosome Disorders; Genetic Diseases, Inborn; Behavior

Limitations and Caveats

The sample size was small (n = 20) and the program duration short (12 weeks), which limits generalizability and makes it unclear whether usability and outcomes would be sustained over longer interventions. The sample was also relatively young (mean age 28.3 years), and none required assistive devices for ambulation, potentially limiting applicability to older adults or those with additional mobility impairments.

Results Point of Contact

• Title: Julianne G. Clina
• Organization: University of Kansas Medical Center

jclina@kumc.edu

913-588-7982

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 18, 2024
• First Posted: August 5, 2024
• Study Start: August 2, 2024
• Primary Completion: May 9, 2025
• Study Completion: May 9, 2025
• Last Updated: March 13, 2026
• Results First Posted: March 13, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)