Down Syndrome
312
52
63
183
Key Insights
Highlights
Success Rate
92% trial completion (above average)
Published Results
40 trials with published results (13%)
Research Maturity
183 completed trials (59% of total)
Clinical Risk Assessment
Based on trial outcomes
Moderate Risk
Score: 50/100
5.1%
16 terminated out of 312 trials
92.0%
+5.4% vs benchmark
5%
17 trials in Phase 3/4
22%
40 of 183 completed with results
Key Signals
Data Visualizations
Phase Distribution
Trial Status
Trial Success Rate
Benchmark: 86.5%
Based on 183 completed trials
Clinical Trials (312)
A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia
Harness-based Mobility Intervention for Infants With Down Syndrome
Non-Invasive Brain Stimulation to Improve Language in Down Syndrome.
Natural History of Dysregulation and Aging of the Immune System in People With Trisomy 21 With and Without Thymectomy
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
MOTOR PROFICIENCY AND HEALTH-RELATED FITNESS IN DOWN SYNDROME
Therapies for Down Syndrome Regression Disorder
Parent and Infant Inter(X)Action Intervention (PIXI)
Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Down Syndrome (TOPS-DS)
The (Cost)Effectiveness of a Social Robot for Persons With Problems in Daily Structure and Planning in Disability Care
Leucettinib-21 First-in-Human Phase 1 in Healthy Volunteers and Subjects With Down Syndrome and Alzheimer's Disease
Positive Airway Pressure (PAP) for Children With Down Syndrome (DS) and Obstructive Sleep Apnea Syndrome (OSAS)
Cholinergic Integrity in Down Syndrome in Association With Aging, Alzheimer's Disease Pathology, and Cognition
Neurodevelopmental Treatment for Balance and Mobility in Children With Down Syndrome
How Simplified Language Affects Comprehension and Learning in Young Children With Down Syndrome
A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)
tDCS for Catatonic Depression in Down Syndrome: A Pilot Study
HomeGrown: A Family-based Lifestyle Intervention to Support Healthy Development of Young Children With Down Syndrome
Home and Community Use of a Suspension Walker in Pre-Walking Infants With Down Syndrome
Collaboration for Down Syndrome Progress (CDP)