Key Insights

Highlights

Success Rate

92% trial completion (above average)

Published Results

40 trials with published results (13%)

Research Maturity

178 completed trials (57% of total)

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 50/100

Termination Rate

5.2%

16 terminated out of 310 trials

Success Rate

91.8%

+5.2% vs benchmark

Late-Stage Pipeline

5%

17 trials in Phase 3/4

Results Transparency

22%

40 of 178 completed with results

Key Signals

40 with results92% success16 terminated

Data Visualizations

Phase Distribution

219Total
Not Applicable (162)
P 1 (11)
P 2 (29)
P 3 (13)
P 4 (4)

Trial Status

Completed178
Recruiting54
Unknown32
Terminated16
Active Not Recruiting12
Not Yet Recruiting9

Trial Success Rate

91.8%

Benchmark: 86.5%

Based on 178 completed trials

Clinical Trials (310)

Showing 20 of 20 trials
NCT06951516Not ApplicableRecruitingPrimary

How Simplified Language Affects Comprehension and Learning in Young Children With Down Syndrome

NCT07416201RecruitingPrimary

Natural History of Dysregulation and Aging of the Immune System in People With Trisomy 21 With and Without Thymectomy

NCT04546399Phase 2RecruitingPrimary

A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)

NCT06866925Not ApplicableRecruitingPrimary

tDCS for Catatonic Depression in Down Syndrome: A Pilot Study

NCT07296861Not ApplicableRecruitingPrimary

HomeGrown: A Family-based Lifestyle Intervention to Support Healthy Development of Young Children With Down Syndrome

NCT07631130Not ApplicableNot Yet RecruitingPrimary

Home and Community Use of a Suspension Walker in Pre-Walking Infants With Down Syndrome

NCT07625579RecruitingPrimary

Collaboration for Down Syndrome Progress (CDP)

NCT04132999Not ApplicableCompletedPrimary

Positive Airway Pressure (PAP) for Children With Down Syndrome (DS) and Obstructive Sleep Apnea Syndrome (OSAS)

NCT01190930Phase 3Completed

Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma

NCT03914625Phase 3Active Not Recruiting

A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia

NCT07598643Phase 2RecruitingPrimary

Modulation of the Immune System in Down Syndrome for Improved Outcomes and Neurodevelopment - 1

NCT07156318Not ApplicableRecruitingPrimary

Drumming Lessons' Influence on Children With Down Syndrome

NCT05231798Phase 2RecruitingPrimary

Cholinergic Integrity in Down Syndrome in Association With Aging, Alzheimer's Disease Pathology, and Cognition

NCT04165109RecruitingPrimary

Trial-Ready Cohort-Down Syndrome (TRC-DS)

NCT03286634Phase 2Active Not RecruitingPrimary

ASIA Down Syndrome Acute Lymphoblastic Leukemia 2016

NCT07531940Phase 1Not Yet RecruitingPrimary

Escalating Doses of Memantine in Down Syndrome (MEDS-123)

NCT06617637Not ApplicableCompletedPrimary

Effects of Aerobic-Based Virtual Reality Exercise Training and Traditional Aerobic Exercise Training on Physical Fitness, Functional Capacity and Cognitive Function in Individuals With Down Syndrome

NCT07578922Not ApplicableRecruitingPrimary

Effects of Bean Bag Tossing Game on Balance and Gait in Children With Down Syndrome.

NCT05059041Phase 2CompletedPrimary

Dilated Versus Non-Dilated Wavefront Corrections for Patients With Down Syndrome

NCT05702645Recruiting

A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute Leukemia

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