Key Insights

Highlights

Success Rate

92% trial completion (above average)

Published Results

40 trials with published results (13%)

Research Maturity

183 completed trials (59% of total)

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 50/100

Termination Rate

5.1%

16 terminated out of 312 trials

Success Rate

92.0%

+5.4% vs benchmark

Late-Stage Pipeline

5%

17 trials in Phase 3/4

Results Transparency

22%

40 of 183 completed with results

Key Signals

40 with results92% success16 terminated

Data Visualizations

Phase Distribution

220Total
Not Applicable (163)
P 1 (11)
P 2 (29)
P 3 (13)
P 4 (4)

Trial Status

Completed183
Recruiting52
Unknown32
Terminated16
Active Not Recruiting11
Not Yet Recruiting9

Trial Success Rate

92.0%

Benchmark: 86.5%

Based on 183 completed trials

Clinical Trials (312)

Showing 20 of 20 trials
NCT03914625Phase 3Active Not Recruiting

A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia

NCT06219863Not ApplicableRecruitingPrimary

Harness-based Mobility Intervention for Infants With Down Syndrome

NCT07044804Not ApplicableRecruitingPrimary

Non-Invasive Brain Stimulation to Improve Language in Down Syndrome.

NCT07416201RecruitingPrimary

Natural History of Dysregulation and Aging of the Immune System in People With Trisomy 21 With and Without Thymectomy

NCT04278404Recruiting

Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

NCT07702201CompletedPrimary

MOTOR PROFICIENCY AND HEALTH-RELATED FITNESS IN DOWN SYNDROME

NCT05662228Phase 2CompletedPrimary

Therapies for Down Syndrome Regression Disorder

NCT03836300Not ApplicableEnrolling By Invitation

Parent and Infant Inter(X)Action Intervention (PIXI)

NCT05508971Not ApplicableRecruiting

Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Down Syndrome (TOPS-DS)

NCT06592404Not ApplicableCompleted

The (Cost)Effectiveness of a Social Robot for Persons With Problems in Daily Structure and Planning in Disability Care

NCT06206824Phase 1Completed

Leucettinib-21 First-in-Human Phase 1 in Healthy Volunteers and Subjects With Down Syndrome and Alzheimer's Disease

NCT04132999Not ApplicableCompletedPrimary

Positive Airway Pressure (PAP) for Children With Down Syndrome (DS) and Obstructive Sleep Apnea Syndrome (OSAS)

NCT05231798Phase 2RecruitingPrimary

Cholinergic Integrity in Down Syndrome in Association With Aging, Alzheimer's Disease Pathology, and Cognition

NCT07653399Not ApplicableCompletedPrimary

Neurodevelopmental Treatment for Balance and Mobility in Children With Down Syndrome

NCT06951516Not ApplicableRecruitingPrimary

How Simplified Language Affects Comprehension and Learning in Young Children With Down Syndrome

NCT04546399Phase 2RecruitingPrimary

A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)

NCT06866925Not ApplicableRecruitingPrimary

tDCS for Catatonic Depression in Down Syndrome: A Pilot Study

NCT07296861Not ApplicableRecruitingPrimary

HomeGrown: A Family-based Lifestyle Intervention to Support Healthy Development of Young Children With Down Syndrome

NCT07631130Not ApplicableNot Yet RecruitingPrimary

Home and Community Use of a Suspension Walker in Pre-Walking Infants With Down Syndrome

NCT07625579RecruitingPrimary

Collaboration for Down Syndrome Progress (CDP)

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