Oxygen Uptake Kinetics During Submaximal Exercise in Adults With Down Syndrome

NCT05995223 | Completed

• 1 other identifier: UNLV-2022-489
• Study Type: interventional
• Target: 28
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to compare the rate at which oxygen uptake adapts to submaximal, moderate intensity exercise (oxygen uptake kinetics) between adults with and without Down syndrome, to determine the contribution of oxygen uptake kinetics to exercise intolerance of adults with Down syndrome. Additionally, the study will investigate the role of oxygen delivery (by the cardiovascular circuit) and oxygen utilization (in the mitochondria) on the oxygen uptake kinetics of adults with Down syndrome to identify specific areas which adults with Down syndrome could benefit from targeting during exercise training. Overall, this study aims to contribute to the knowledge on the exercise capacity of adults with Down syndrome, in order to improve the way adults with Down syndrome participate in and benefit from exercise. Participants will perform a maximal exercise test on a treadmill, and walk on a treadmill at a submaximal, moderate intensity speed and incline, during which oxygen uptake at the lungs, cardiac output, and oxygen utilization in the muscle will be measured.

Conditions

Down Syndrome

Keywords

Down syndrome; cardiorespiratory fitness; oxygen uptake; cardiac output; mitochondrial oxygen utilization

Outcome Measures

Primary Outcomes (1)

• Oxygen uptake kinetics

  The finite rate at which oxygen uptake (measured with breath-by-breath gas exchange analysis at the mouth) adapts to a (submaximal) increase in exercise intensity, primarily captured by time constant tau, which describes the time needed to reach 63% of the required, steady state oxygen uptake

  Through study completion, on average 4 hours

Secondary Outcomes (13)

• Cardiac output kinetics

  Through study completion, on average 4 hours

• Muscle deoxygenation kinetics

  Through study completion, on average 4 hours

• Steady-state cardiac output

  Through study completion, on average 4 hours

• Absolute peak oxygen uptake

  Through study completion, on average 4 hours

• Relative peak oxygen uptake (corrected for total body mass)

  Through study completion, on average 4 hours

Study Arms (2)

Down syndrome

EXPERIMENTAL

Participants will complete a submaximal walking protocol on a motorized treadmill, which consists of 4 times 6 minutes of walking at a moderate intensity speed and incline while their breathing, cardiac output, and muscle oxygen use is measured, with 10 minutes rest in between each bout.

Other: Submaximal exercise protocol

control without Down syndrome

EXPERIMENTAL

This group of age- and sex-matched participants without Down syndrome will undergo the same testing as participants with Down syndrome

Other: Submaximal exercise protocol

Interventions

Submaximal exercise protocol OTHER

Participants will complete a submaximal walking protocol on a motorized treadmill, which consists of 4 times 6 minutes of walking at a moderate intensity speed and incline while their breathing, cardiac output, and muscle oxygen use is measured, with 10 minutes rest in between each bout.

Down syndrome; control without Down syndrome

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• low active (defined as being involved in less than 30 minutes of moderately-intense physical activity per day);
• diagnosis with Down syndrome trisomy 21 (Down syndrome group only);
• normal thyroid function or stable thyroid function (with medications) for at least 6 months (Down syndrome group only).

You may not qualify if:

• asthma or other pulmonary disease;
• severe obesity (defined as BMI \>40);
• uncontrolled hypertension (defined as blood pressure \>130/80 mmHg);
• congenital heart disease;
• diabetes (defined as Hba1c of \>7.5% or use of glucose lowering medication);
• current smoking;
• pregnancy.

Sponsors & Collaborators

• University of Nevada, Las Vegas: lead

Study Sites (1)

University of Nevada, Las Vegas

Las Vegas, Nevada, 89154, United States

Location

MeSH Terms

Conditions

Down Syndrome

Condition Hierarchy (Ancestors)

Intellectual Disability; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Abnormalities, Multiple; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Chromosome Disorders; Genetic Diseases, Inborn

Study Officials

• Victor DY Beck, MS

  University of Nevada, Las Vegas

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: SCREENING
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Graduate Research Assistant

Study Record Dates

• First Submitted: June 29, 2023
• First Posted: August 16, 2023
• Study Start: October 4, 2023
• Primary Completion: June 27, 2024
• Study Completion: June 27, 2024
• Last Updated: July 1, 2024

Record last verified: 2024-06

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)