NCT06536569

Brief Summary

This study is a Single center, prospective, observational, multi surgeon randomized controlled trial. Subjects will be assessed pre-operatively, operatively and at 1 month postoperatively. Clinical evaluations will include measurement of visual acuity and optical coherence tomography (OCT).

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
56

participants targeted

Target at P25-P50 for phase_4

Timeline
Completed

Started Jul 2025

Shorter than P25 for phase_4

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

July 22, 2024

Completed
14 days until next milestone

First Posted

Study publicly available on registry

August 5, 2024

Completed
11 months until next milestone

Study Start

First participant enrolled

July 1, 2025

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2025

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2026

Completed
Last Updated

March 30, 2025

Status Verified

July 1, 2024

Enrollment Period

5 months

First QC Date

July 22, 2024

Last Update Submit

March 25, 2025

Conditions

Outcome Measures

Primary Outcomes (1)

  • Number of attempts to initiate peeling

    Evaluated by recorded video

    Surgery (Operative Visit)

Secondary Outcomes (3)

  • Number of handle-ReSite/widefield viewing system lens touches

    Surgery (Operative Visit)

  • Duration of Peel

    Surgery (Operative Visit)

  • Number of deep retinal grasps

    Surgery (Operative Visit)

Other Outcomes (1)

  • Corrected Distance Visual Acuity

    1 Month Postoperatively

Study Arms (2)

Sharkskin Group

EXPERIMENTAL

25g Grieshaber Sharkskin ILM Forceps with Reflex Handle

Device: Internal limiting membrane (ILM) Peeling with Sharkskin Forceps

Standard Group

ACTIVE COMPARATOR

25g Grieshaber standard ILM

Device: Internal limiting membrane (ILM) Peeling with Standard Forceps

Interventions

25g Grieshaber Sharkskin ILM Forceps with Reflex Handle

Sharkskin Group

25g Grieshaber Standard ILM Forceps

Standard Group

Eligibility Criteria

Age19 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • 19y and older patients with symptomatic ERM (grade 2-3) or Macular hole (non flap-requiring) for elective ILM peeling surgery.

You may not qualify if:

  • Co-morbid diabetic retinopathy of any grade.
  • Neovascular AMD.
  • Previous vitrectomy.
  • Previous retinal detachment treated with scleral buckle or pneumatic retinopexy.
  • Uncontrolled glaucoma or previous glaucoma surgery.
  • Combined phacovitrectomy.
  • Macula holes with severity requiring flap.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Department of Ophthalmology & Visual Sciences, St Paul's Hospital, Ophthalmology

Vancouver, British Columbia, V6Z 1Y6, Canada

Location

MeSH Terms

Conditions

Retinal PerforationsEpiretinal Membrane

Interventions

Weights and Measures

Condition Hierarchy (Ancestors)

Retinal DiseasesEye Diseases

Intervention Hierarchy (Ancestors)

Investigative Techniques

Study Officials

  • Bryon McKay, MD, PhD

    UBC

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Bryon McKay, MD, PhD

CONTACT

Study Design

Study Type
interventional
Phase
phase 4
Allocation
RANDOMIZED
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

July 22, 2024

First Posted

August 5, 2024

Study Start

July 1, 2025

Primary Completion

December 1, 2025

Study Completion

January 1, 2026

Last Updated

March 30, 2025

Record last verified: 2024-07

Data Sharing

IPD Sharing
Will not share

Locations