Brief Summary

If pulmonary hypertension is suspected, a right heart catheterization is usually performed to confirm or rule out the diagnosis. As part of this examination, blood samples are taken from various locations as standard and blood gas analyses are performed. One of the most important measurements during the right heart catheterization is the measurement of the pulmonary arterial occlusion pressure by the so-called wedge maneuver. To measure this value, the catheter with inflated balloon must be advanced into the pulmonary vessels until the "wedge" position is reached, i.e. the balloon completely occludes a branch of the pulmonary artery. In this study, the investigators want to characterize patients with pulmonary hypertension of different causes in more detail. To do that, two blood samples (totaling approximately 4 mL of blood, one sample directly after occlusion and the other one two minutes later) will be drawn during the right heart catheterization from the above-mentioned "wedge" position", behind the inflated balloon, and blood gas analyses will be performed on these samples. In addition, various clinical parameters (comorbidities, etc.) will be recorded by means of clinical questionnaires. Follow-up data will be analyzed and correlations with the aforementioned blood gas analyses will be examined. The results of the study will be used to more precisely characterize the still vague concept of secondary pulmonary hypertension. This could help to develop new therapeutic strategies in some subgroups in the future.

Trial Health

On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment

100

participants targeted

Target at P50-P75 for all trials

Timeline

2mo left

Started Jun 2021

Longer than P75 for all trials

Geographic Reach

1 country

1 active site

Status

recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

5 years study duration

Study Progress97%

Jun 2021Jun 2026

Study Start

First participant enrolled

June 25, 2021

Completed

1 month until next milestone

First Submitted

Initial submission to the registry

July 30, 2021

Completed

7 days until next milestone

First Posted

Study publicly available on registry

August 6, 2021

Completed

4.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 30, 2026

Expected

Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 30, 2026

Last Updated

February 6, 2026

Status Verified

January 1, 2026

Enrollment Period

5 years

First QC Date

July 30, 2021

Last Update Submit

February 3, 2026

Conditions

Pulmonary Hypertension

Outcome Measures

Primary Outcomes (1)

Between group differences
Differences in the Wedge-BGA between groups
At the time of recruitment