Early Diagnosis of Acute Renal Failure by Urine Trehalase Levels.

NCT06505655 | Not Yet Recruiting

• 1 other identifier: istinye university trehalase
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

We think that in surgical patients requiring hypotensive anesthesia, acute kidney injury, which may occur due to intraoperative renal hypoperfusion, can be diagnosed early by evaluating the urine trehalase value using the ELISA method, and thus, early diagnosed acute renal failure can be treated quickly and patients can be protected from subsequent complications in the postoperative period.

Conditions

Trehalase Levels; Acute Kidney Injury

Outcome Measures

Primary Outcomes (1)

• trehalase levels

  urine trehalase levels

  1 month

Interventions

trehalase levels DIAGNOSTIC_TEST

We think that in surgical patients requiring hypotensive anesthesia, acute kidney injury, which may occur due to intraoperative renal hypoperfusion, can be diagnosed early by evaluating the urine trehalase value using the ELISA method

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

40 patients between the ages of 18-65 who underwent a surgical operation requiring hypotensive anesthesia will be included in the study.

You may qualify if:

• Being over the age of 18 and under the age of 65
• Having signed the BGOF form to be included in the study,
• Being in ASA 1 or ASA 2 classification
• Not having kidney failure or kidney disease
• No history of single kidney or renal transplantation
• Not using nephrotoxic drugs or agents before surgery
• Renal function tests taken preoperatively should be within normal ranges.
• No urinary tract infection or urinary problems (such as polyuria, oliguria or anuria)

You may not qualify if:

• Those under the age of 18 or over the age of 65
• Those who do not want to participate in the study
• ASA 3 and above
• Having previously received treatment for kidney disease - including kidney stones -
• Having been previously diagnosed with acute or chronic renal failure
• Having a single kidney or a history of renal transplantation
• Using nephrotoxic drugs or agents (such as contrast material) before surgery
• Kidney function tests taken preoperatively are not within normal ranges
• Having a urinary tract infection or urinary problem (such as polyuria, oliguria or anuria)
• Having a history of kidney stones, acute renal failure or chronic renal failure
• Those with active infection or disease before surgery
• They were determined as patients for whom consent was not obtained for the study.

Sponsors & Collaborators

• Istinye University: lead

Study Sites (1)

Istinye Üniversity

Istanbul, Merkez Mahallesi, 34250, Turkey (Türkiye)

Location

Related Publications (4)

• Chavan S, Hase N, Chavan P. Urinary enzymes in nephrotic syndrome. Indian J Clin Biochem. 2005 Jul;20(2):126-30. doi: 10.1007/BF02867411.

  PMID: 23105544 BACKGROUND

• Ouyang Y, Xu Q, Mitsui K, Motizuki M, Xu Z. Human trehalase is a stress responsive protein in Saccharomyces cerevisiae. Biochem Biophys Res Commun. 2009 Feb 6;379(2):621-5. doi: 10.1016/j.bbrc.2008.12.134. Epub 2009 Jan 4.

  PMID: 19126402 BACKGROUND

• Sasai-Takedatsu M, Kojima T, Taketani S, Ono A, Kitamura N, Kobayashi Y. Urinary trehalase activity is a useful marker of renal proximal tubular damage in newborn infants. Nephron. 1995;70(4):443-8. doi: 10.1159/000188643.

  PMID: 7477650 RESULT

• Sasai-Takedatsu M, Taketani S, Nagata N, Furukawa T, Tokunaga R, Kojima T, Kobayashi Y. Human trehalase: characterization, localization, and its increase in urine by renal proximal tubular damage. Nephron. 1996;73(2):179-85. doi: 10.1159/000189037.

  PMID: 8773341 RESULT

MeSH Terms

Conditions

Acute Kidney Injury

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Central Study Contacts

ilke dolgun

CONTACT

+905555485632; ilkeser2004@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assoc. prof

Study Record Dates

• First Submitted: July 11, 2024
• First Posted: July 17, 2024
• Study Start: July 15, 2024
• Primary Completion: August 15, 2024
• Study Completion: September 15, 2024
• Last Updated: July 17, 2024

Record last verified: 2024-07

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)